Search for dissertations about: "PBMC"

Showing result 11 - 15 of 120 swedish dissertations containing the word PBMC.

  2. 11. Autoantibodies and the Type I Interferon System in the Etiopathogenesis of Systemic Lupus Erythematosus

    Author : Stina Blomberg; Johan Frostegård; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Systemic lupus erythematosus; type I interferon; interferon inducer; dendritic cell; natural interferon-alpha producing cell; immune complex; SSA Ro; dsDNA; BDCA; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; Medicine; medicin;

    Abstract : In sera remitted for anti-nuclear antibody (ANA) analysis, the supplement of a sensitive anti-SSA/Ro ELISA to the conventional ANA screening by immunofluorescence (IF) revealed that one fourth of the individuals with IF-ANA negative, but SSA/Ro ELISA positive sera, had systemic lupus erythematosus (SLE) or cutaneous LE. Consequently, adding a sensitive anti-SSA/Ro ELISA to the ANA screening is valuable for the serological detection of ANA negative SLE/LE patients. READ MORE

  4. 12. Evaluation of HIV testing strategies and monitoring of immune responses in HIV-vaccinated individuals in Tanzania

    Author : Said Aboud; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : This thesis describes studies on the evaluation of human immunodeficiency virus (HIV) enzyme-linked immunosorbent assays (ELISAs) and simple rapid HIV assays for use in HIV testing strategies in resource-limited settings and studies of HIV vaccine-induced immune responses. Peripheral blood mononuclear cell (PBMC) preparation techniques were also studied in preparation for use in the HIV vaccine trials. READ MORE

  5. 13. THE INFLUENCE OF LACTOBACILLI AND STAPHYLOCOCCUS AUREUS ON IMMUNE RESPONSIVENESS IN VITRO

    Author : Yeneneh Haileselassie; Eva Sverremark-Ekström; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cytokine; T cells; immune response; HT-29; Intestinal epithelial cells; Lactobacillus; Staphylococcus aureus; bacteria and infants; immunologi; Immunology;

    Abstract : Alteration of gut microbiota has been associated with development of immune mediated diseases, such as allergy. In part, this could be due to the influence of microbes in shaping the immune response. READ MORE

  6. 14. The role of anti-collagen type II antibodies in the pathogenesis and prognosis of rheumatoid arthritis

    Author : Vivek Anand Manivel; Johan Rönnelid; Arne Egesten; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rheumatoid arthritis; Anti-collagen type II antibodies; HLADRB1*; Granulocytes; prognosis; ;

    Abstract : Rheumatoid arthritis (RA) which affects 0.5-1% of the world population and is characterised by joint erosions and presence of the autoantibodies anti-citrullinated protein antibodies (ACPA) and rheumatoid factor. READ MORE

  7. 15. Inflammation modulating effects of prostaglandins and omega-3 fatty acids

    Author : Inger Vedin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Omega-(omega6) and omega-3 fatty acids (FA) and their metabolites (eikosanoids, such as prostaglandins, PG) are important modulators of immune and inflammatory responses in various ways. The aim of this thesis was to assess some in vitro and ex vivo effects of these lipids on blood leukocytes. READ MORE