Search for dissertations about: "PBN"

Showing result 16 - 20 of 22 swedish dissertations containing the word PBN.

  2. 16. Sex differences in behavior and metabolism

    Author : Ivana Maric; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sex differences; eating; brown adipose tissue; motivation; anxiety-like behavior;

    Abstract : Men and women exhibit distinct illness patterns and disparate responses to pharmacotherapies. However, there is a scarcity of preclinical studies that systematically compare the sexes. READ MORE

  4. 17. Common mechanism for teratogenicity of antiepileptic drugs : Drug-induced embryonic arrhythmia and hypoxia-reoxygenation damage

    Author : Faranak Azarbayjani; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Atiepileptik drugs; embryonic heart; arrhythmia; cleft palate; ROS; antioxidants; Ikr; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Toxicology; toxikologi;

    Abstract : The Antiepilptic drugs (AEDs) phenytoin (PHT), carbamazepine (CBZ), phenobarbital (PB), tri- and dimethadione (TMD and DMD) are known teratogens having a common malformation pattern in human and animal studies. This thesis was designed chiefly to test a hypothesis correlating the teratogenicity of these AEDs to episodes of pharmacologically induced embryonic arrhythmia and hypoxia-reoxygenation damage. READ MORE

  5. 18. Central actions of glucagon-like peptide-1 on food intake and reward: Novel neurological targets and sex divergent effects

    Author : Jennifer E. Richard; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glucagon-like peptide-1; Food reward; Food intake; GLP-1; Sex differences;

    Abstract : Obesity is one of the biggest health risks of our society; however, treatment options are sparse and often result in suboptimal weight-loss. The glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) agonist liraglutide was recently approved for treatment of obesity in the US. READ MORE

  6. 19. Mechanisms of traumatic brain injury in the rat : Morphological consequences and neurotrophic responses

    Author : Anders Lewén; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Cortical contusion injury; TBI; neurons; axons; dendrites; APP; MAP2; BMPR-II; ActR-I; trkB; c-fos; BDNF; PACAP; TUNEL; TGFs; serine threonine; bone morphogenetic protein; neuropeptides; reactive oxygen species; ROS; apoptosis; Neurovetenskap; Neurology; Neurologi; Neurosurgery; neurokirurgi;

    Abstract : Traumatic brain injury is a major cause of death and disability in the Western world. especially in young people. Understanding the pathophysiology of traumatic brain injury is the basis for further development of better therapeutic strategies for such patients. READ MORE

  7. 20. Heavy metal neurotoxicity : on trimethyltin-, methylmercury- and cadmium-induced disturbances of neurotransmitter systems and neurotrophins

    Author : Helena Andersson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : neurotoxicity; trimethyltin; methylmercury; cadmium; development; GFAP; GABA; noradrenalin; BDNF; c-fos; hsp70; glial glutamate transporter;

    Abstract : Organic and inorganic metal compounds produced by human activities often reach the environment where they are associated with a plethora of potential health hazards. Of particular concern is the risk for CNS disturbances during development or in the adult. READ MORE