Search for dissertations about: "PD-1"
Showing result 21 - 25 of 60 swedish dissertations containing the word PD-1.
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21. Modulation of invariant NKT cell activity by cytokines and receptors in human disease
Abstract : Invariant natural killer T (NKT) cells are innate-like lymphocytes with both immunoregulatory and cytotoxic functions that play a role as activators and regulators of the immune response in many diseases. NKT cells are believed to bridge the innate and adaptive immune systems by rapidly producing large quantities of cytokines after recognition of CD1d-presented lipid antigens. READ MORE
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22. Novel immunotherapies for metastatic uveal melanoma - From bench to clinical biomarkers
Abstract : Immunotherapy has revolutionized cancer treatment, with durable long-term effects in a proportion of patients. However, in around half of these patients, there are little to no effects. Patients with metastatic uveal melanoma (mUM), a rare form of melanoma originating from the eye has lack of effective treatments. READ MORE
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23. Immunomodulatory Effects of Human ImmunodeficiencyVirus (HIV-1) on Dendritic Cell and T cell Responses : Studies of HIV-1 effects on Dendritic cell functionality reflected in primed T cells
Abstract : The human immunodeficiency virus (HIV)-1 is the causative agent of acquired immune deficiency syndrome (AIDS) worldwide. Till date there are no vaccines or cure for this infection as the virus has adapted myriad ways to remain persistent in the host where it causes severe damage to the immune system. READ MORE
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24. Discovering circulating protein biomarkers through in-depth plasma proteomics
Abstract : Plasma, i.e., the liquid component of blood, is one of the most clinically used samples for biomarker measurement. READ MORE
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25. Exploring the therapeutic effects of p53 modulation in cancer and immune cell biology
Abstract : The tumor suppressor protein p53 is dysregulated in almost all cancer. In around 50% of cancer p53 retains wild type activity but its inactivation by the E3 ligase MDM2 in a heterodimer complex with MDMX may be amplified, leading to loss of p53 activity. READ MORE