Search for dissertations about: "PDCD1"
Showing result 1 - 5 of 7 swedish dissertations containing the word PDCD1.
-
1. Systemic lupus erythematosus and rheumatoid arthritis : analyses of candidate genes involved in immune functions, for susceptibility and severity
Abstract : Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease with systemic manifestations characterized by auto-antibodies directed against different parts of the cell nucleus including DNA, histones and ribosomes. The systemic inflammation can cause damage to multiple organs, e.g., kidneys, skin, heart, lungs and the nervous system. READ MORE
-
2. Genetic analysis of type 1 diabetes susceptibilty
Abstract : Type 1 diabetes (T1D) is a multifactorial disease where the pancreatic beta-cells are destroyed in an autoimmune attack. For the patients, this in turn leads to lifelong daily insulin treatment and increased risk for various kinds of complications. It is thought that both environmental as well as genetic factors act in concert to cause T1D. READ MORE
-
3. Genetic analysis of candidate susceptibility genes for type 1 diabetes
Abstract : Type 1 diabetes (T1D) is a complex disease where the pancreatic β-cells are destroyed in an autoimmune attack. For the patients, this leads to lifelong daily insulin treatment and increased risk for various kinds of complications. It is thought that both environmental as well as genetic factors act in concert to cause T1D. READ MORE
-
4. Genetic studies on Systemic Lupus Erythematosus : A fine mapping and candidate gene approach
Abstract : Linkage in the 2q37 region was evaluated using microsatellite markers in multi-case families from Sweden, Iceland and Norway. Both the two-point and the multipoint linkage analysis show highly significant LOD scores (Z=4.51 and 6.03, respectively). READ MORE
-
5. Strategies for Identification of Susceptibility Genes in Complex Autoimmune Diseases
Abstract : Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are complex autoimmune diseases affecting 0.05-2% of the population worldwide. Genetic studies detected linkage with SLE in the 2q37 region, and intensive family-based and case-control association studies in several populations identified that allele A of the SNP PD-1. READ MORE