Search for dissertations about: "PDE3"

Showing result 1 - 5 of 8 swedish dissertations containing the word PDE3.

  1. 1. Cyclic nucleotide signalling systems in vascular smooth muscle cells and immune system cells with special reference to phosphodiesterases PDE3 and PDE4

    University dissertation from Department of Cell and Molecular Biology, Lund University

    Author : Dag Ekholm; [1998]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HTLV-I; multiple sclerosis; proliferation; phosphorylation; T-lymphocytes; vascular smooth muscle; cloning; protein kinase A; cGMP; cAMP; PDE4; Phosphodiesterase; PDE3; cilostamide; rolipram; Histology; cytochemistry; histochemistry; tissue culture; Histologi; cytokemi; histokemi; vävnadskultur;

    Abstract : The cyclic nucleotide signalling systems are important in vascular smooth muscle and in the immune system, and are of interest from a pharmacological point of view. Drugs which interfere with the cyclic nucleotide levels have profound effects on heart, blood vessels and airways and have actual or potential use in several important diseases, such as heart failure, hypertension, arteriosclerosis, asthma and autoimmune diseases. READ MORE

  2. 2. Mechanisms of Growth Hormone Signal Transduction - Studies on the insulin-like metabolic effects in primary rat adipocytes

    University dissertation from Hans Eriksson, Department of Cell and Molecular Biology, Section for Cell Signalling, Lund University, P.O. Box 94, S-221 00 Lund, Sweden

    Author : Hans Eriksson; [1996]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fysiologi; Endocrinology; Growth hormone insulin receptor phosphorylation phosphotyrosine cAMP phosphodiesterase phospholipid JAK2 rat adipocyte lipolysis lipogenesis; Physiology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

    Abstract : Growth hormone (GH) exerts growth-promoting and metabolic effects in mammals. The metabolic effects of GH in adipose tissue are insulin-antagonistic or insulin-like. Cells that just have been exposed to GH are insensitive to the hormone. READ MORE

  3. 3. Functional Aspects of the Juxtaglomerular Apparatus Control of Glomerular Filtration and Renin Release

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Johan Sällström; Erik Persson; Peter Hansell; Jürgen Schnermann; [2010]

    Abstract : The juxtaglomerular apparatus (JGA) is a control unit of the kidney, that regulates glomerular filtration rate (GFR) and renin release, and hence extracellular volume and blood pressure. The tubuloglomerular feedback (TGF) mechanism is a negative feedback loop that regulates GFR. READ MORE

  4. 4. The Role of Phosphodiesterase 3B in the Regulation of Insulin Secretion

    University dissertation from Linda Härndahl, C11 BMC, SE-221 84 Lund

    Author : Linda Härndahl; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; Endokrinologi; sekretion; diabetologi; secreting systems; Endocrinology; beta-cell; diabetes; islet; PDE3B; cAMP;

    Abstract : Pancreatic beta-cell dysfunction and insulin resistance are the two hallmarks of type 2 diabetes. An early sign of beta-cell dysfunction is impaired nutrient-induced insulin release. Several insulin secretagogues act by increasing the formation of intracellular cAMP. READ MORE

  5. 5. Pharmacological evaluation of the NO/cGMP signalling system

    University dissertation from Linköping : Linköping University Electronic Press

    Author : Anna Asplund Persson; Karl-Erik Andersson; [2005]

    Abstract : Platelet activation and inhibition are tightly balanced processes, regulated by various endogenous molecules. In this regard, the endothelium plays a key role in mediating inhibition of platelets by releasing nitric oxide (NO) and cAMP-elevating prostaglandins. READ MORE