Search for dissertations about: "PDE6"

Found 3 swedish dissertations containing the word PDE6.

  2. 1. Evolution of Vertebrate Vision by Means of Whole Genome Duplications : Zebrafish as a Model for Gene Specialisation

    Author : David Lagman; Dan Larhammar; Xesús M Abalo; Finn Hallböök; Stephan Neuhauss; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; phylogenetics; evolution; vision; visual opsin; transducin; PDE6; genome duplications; subfunctionalisation; Medicinsk vetenskap; Medical Science;

    Abstract : The signalling cascade of rods and cones use different but related protein components. Rods and cones, emerged in the common ancestor of vertebrates around 500 million years ago around when two whole genome duplications took place, named 1R and 2R. READ MORE

  4. 2. Genes and proteins controlled by cGMP-PKG during retinal degeneration

    Author : Jiaming Zhou; Lund Oftalmologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; retinal degeneration; cell death; cGMP-PKG; organotypic explant culture; RNA sequencing; mass spectrometry;

    Abstract : prevalence was reported as 1:3000-4000 worldwide, making it the main reason for blindness in the working population in industrial countries. The mutations of over 70 genes have been related to this genetic disorder, and there is generally no effective treatment, except for gene therapy for the RPE65 mutations. READ MORE

  5. 3. Cyclic nucleotide signalling systems in vascular smooth muscle cells and immune system cells with special reference to phosphodiesterases PDE3 and PDE4

    Author : Dag Ekholm; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HTLV-I; multiple sclerosis; proliferation; phosphorylation; T-lymphocytes; vascular smooth muscle; cloning; protein kinase A; cGMP; cAMP; PDE4; Phosphodiesterase; PDE3; cilostamide; rolipram; Histology; cytochemistry; histochemistry; tissue culture; Histologi; cytokemi; histokemi; vävnadskultur;

    Abstract : The cyclic nucleotide signalling systems are important in vascular smooth muscle and in the immune system, and are of interest from a pharmacological point of view. Drugs which interfere with the cyclic nucleotide levels have profound effects on heart, blood vessels and airways and have actual or potential use in several important diseases, such as heart failure, hypertension, arteriosclerosis, asthma and autoimmune diseases. READ MORE