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Showing result 1 - 5 of 10 swedish dissertations matching the above criteria.

  2. 1. Functions of PDGF-A and -C. Essential ligands for the PDGF alpha receptor

    Author : Hans Boström; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; platelet-derived growth factor; PDGF-A; PDGF-C; PDGF alpha receptor; extracellular retention; gene targeting; mouse development; epithelial-mesenchymal interaction; lung; alveolar formation; spina bifida; gastrointestinal villus;

    Abstract : Altered protein kinase activity is a contributing factor in many diseases including most formsof human malignancies, and there is reason to believe that protein kinases will prove to be majordrug targets in the treatment of cancer. Protein kinases mediate most of the signal transduction ineukaryotic cells, regulating cellular events such as transcription, metabolism, proliferation,cytoskeletal rearrangement, migration, differentiation and apoptosis. READ MORE

  4. 2. Growth factor signaling in the breast tumor microenvironment

    Author : Matteo Bocci; Avdelningen för translationell cancerforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; Tumor microenvironment; Angiogenesis; Cancer-associated fibroblasts; PDGF-C; ALK1;

    Abstract : Cancer represents a collection of malignancies characterized by an aberrant expansion of cells. This unrestrained growth is the result of the acquisition of several pro-survival features and the evasion of cellular fail-safe mechanisms, collectively known as the hallmarks of cancer. READ MORE

  5. 3. tPA mediated activation of PDGF-C/PDGFRα signaling in the CNS

    Author : Christina Stefanitsch; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The platelet derived growth factors (PDGFs) and their tyrosine kinase receptors play an essential role during development, in adult tissue homeostasis and in several pathological events. PDGF-CC, a ligand for PDGFRα, is secreted as an inactive dimer. READ MORE

  6. 4. Biological activities of novel platelet-derived growth factors, PDGF-C and PDGF-D

    Author : Annica Pontén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Platelet-derived growth factors (PDGFs) belong to the PDGF/VEGF (vascular endothelial growth factor) family of growth factors. Members of this family share a common structural feature, a conserved PDGF/VEGF homology domain, containing eight invariant cysteine residues. READ MORE

  7. 5. On vascular endothelial growth factor B and platelet-derived growth factor C : two members of the VEGF/PDGF family of growth factors

    Author : Karin Aase; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Vascular endothelial growth factors (VEGFs), platelet-derived growth factors (PDGFs) and their receptors are important for normal development. They have also been implicated in many pathological conditions. VEGFs have been shown to play an important role in the development of both blood and lymphatic vessels. READ MORE