Search for dissertations about: "PDGF"

Showing result 1 - 5 of 175 swedish dissertations containing the word PDGF.

  1. 1. Functions of PDGF-A and -C. Essential ligands for the PDGF alpha receptor

    University dissertation from Göteborg

    Author : Hans Boström; Göteborgs universitet.; Gothenburg University.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; platelet-derived growth factor; PDGF-A; PDGF-C; PDGF alpha receptor; extracellular retention; gene targeting; mouse development; epithelial-mesenchymal interaction; lung; alveolar formation; spina bifida; gastrointestinal villus;

    Abstract : Altered protein kinase activity is a contributing factor in many diseases including most formsof human malignancies, and there is reason to believe that protein kinases will prove to be majordrug targets in the treatment of cancer. Protein kinases mediate most of the signal transduction ineukaryotic cells, regulating cellular events such as transcription, metabolism, proliferation,cytoskeletal rearrangement, migration, differentiation and apoptosis. READ MORE

  2. 2. PDGF in cerebellar development and tumorigenesis

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Johanna Andræ; Uppsala universitet.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; cerebellum; medulloblastoma; PDGF; GFAP; transgenic mice; Genetik; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik; Pathology; patologi;

    Abstract : Medulloblastoma is a highly malignant cerebellar childhood tumor. As in many other brain tumors, expression of platelet-derived growth factor (PDGF) and its receptors has been shown in medulloblastoma. READ MORE

  3. 3. Conditional targeting of the PDGF-B gene

    University dissertation from Göteborg

    Author : Maria Enge; Göteborgs universitet.; Gothenburg University.; [2002]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gene targeting; Cre loxP; PDGF; pericytes; diabetic retinopathy; brain injury; neurons;

    Abstract : Platelet derived growth factors (PDGF) are known as mitogens for fibroblasts, smooth muscle cells (SMC) and glia cells in culture. Previous in vivo analyses have shown that PDGF-B is necessary for normal embryonic development and life after birth, but the relative importance of the various cellular sources of PDGF-B during development has not been clarified. READ MORE

  4. 4. Roles of PDGF for Neural Stem Cells

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Mia Enarsson; Uppsala universitet.; [2004]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; CNS; stem cells; neuron; PDGF; proliferation; differentiation; ERK; microarray; transgenic mouse; Utvecklingsbiologi; NATURAL SCIENCES Biology Organism biology Developmental biology; NATURVETENSKAP Biologi Organismbiologi Utvecklingsbiologi;

    Abstract : Stem cells are endowed with unique qualities: they can both self-renew and give rise to new mature cell types. Central nervous system (CNS) stem cells can give rise to neurons and glia. READ MORE

  5. 5. Hypoxia, PDGF and VEGF in Vascular Development

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Ingrid Nilsson; Uppsala universitet.; [2006]
    Keywords : Cell biology; hypoxia; VEGF; VEGFR-3; PDGF; endothelial cell; embryonic stem cell; angiogenesis; lymphangiogenesis; Cellbiologi;

    Abstract : The mechanisms behind many important aspects of blood- and lymphatic vessel formation have yet not been elucidated in detail. The primary objectives of this thesis have therefore been to study the effects of hypoxia, platelet-derived growth factor (PDGF) and vascular endothelial growth factors (VEGFs) on vascular development and function. READ MORE