Search for dissertations about: "PDX model"

Showing result 6 - 10 of 11 swedish dissertations containing the words PDX model.

  2. 6. The importance of Cyclophilins and Mps1 in cancer

    Author : Sonia Simon Serrano; Klinisk neurofysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cyclophilins; liver; fibrosis; HCC; cell cycle; Mps1 and mitosis;

    Abstract : Hepatic fibrosis is a pathological response to chronic liver injuries such as chronic alcohol consumption, non-alcoholic fatty liver disease (NAFLD) or chronic viral infections. No antifibrotic compound has been approved for liver fibrosis and if the cause of the chronic injury is not solved, fibrosis can progress to cirrhosis. READ MORE

  4. 7. Microenvironmental Impact on Tumour Cell Phenotype and Genotype in Adult and Paediatric Tumours

    Author : Hiroaki Yasui; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer genotype; cancer phenotype; malignant rhabdoid tumour; neuroblastoma; ovarian cancer; tumour evolution; Wilms tumour;

    Abstract : This thesis explores how the tumour microenvironment affects the phenotype and shapes the evolution of cancer cells. It encompasses four separate studies:First, we explored the effect of chemokines on the peritotumoral microenvironment of ovarian cancer. READ MORE

  5. 8. PAK4 in organ development and cancer initiation

    Author : Parisa Rabieifar; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Tumors are complex organs with a unique ecosystem containing tumor cells entangled with various infiltrating cells. Tumors have distinct signaling signatures, which confers upon it the ability to grow in the primary host organ and further disseminate to other parts of the body. READ MORE

  6. 9. Regulation of insulin secretion in diabetes: Molecular mechanism and applications

    Author : Rui Wu; Diabetes - öpatofysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Insulin production secretion; CaV channels; DEGs; aging; magnetic field;

    Abstract : Diabetes is a highly ageing-related disease manifesting with a deteriorated capacity of insulin secretion and uncontrolled blood glucose-raising, hyperglycemia. In this thesis, we aim to explore the underlying roles of CaV channels and aging-associated genetic changes in the development of Type 2 diabetes (T2D). READ MORE

  7. 10. Targeting Myc-driven tumours - BETing on ATR

    Author : Somsundar Veppil Muralidharan; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Cancer arises from loss of function of tumour suppressors and/or gain of function mutations in proto-oncogenes that disrupt the delicate balance required for homeostatic cell division, resulting in uncontrolled cell proliferation. Oncogenic transformation of multifaceted proto-oncogene - transcription factor - MYC can give rise to cancers and it is found to be deregulated in more than 70% of the tumours. READ MORE