Search for dissertations about: "PDX"

Showing result 1 - 5 of 29 swedish dissertations containing the word PDX.

  2. 1. Using genetics to identify epigenetic and signal transduction targets in cancer

    Author : Joydeep Bhadury; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; BETi; HDACi; ATRi; miRNA; NGS; PDX; CDX;

    Abstract : Cancer arises mostly due to the stepwise acquisition of untamed growth capabilities by various means, ranging from genetic, epigenetic to environmental factors. With the advancement made in molecular biology and associated fields, the complex biological circuits leading to these pathological conditions have now started to be deciphered in-depth. READ MORE

  4. 2. Translational and clinical aspects of pancreatic cancer

    Author : Caroline Vilhav; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pancreatic cancer; circulating tumor cells; extracellular vesicles; immunotherapy; PDX model; pancreaticoduodenectomy; postoperative complications; postpancreatectomy hemorrhage;

    Abstract : Pancreatic cancer is a disease with dismal prognosis due to late detection and ineffective treatments. The majority of the patients already have disseminated disease at the time of diagnosis. The only potential curative treatment, surgery, is extensive with high morbidity and non-ignorable mortality. READ MORE

  5. 3. Markers of differentiation and prognosis in prostate cancer : a morphological and immunohistochemical study

    Author : Axel Glaessgen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Prostate cancer (PCa) is the most common malignancy in men worldwide. The disease shows a wide range of patient outcome between indolent and highly aggressive tumor behavior. Prognostic factors are needed to stratify PCa patients in different prognostic groups for treatment decision and to predict outcome. READ MORE

  6. 4. Transcriptional regulation of healthy and diabetic pancreatic beta-cell gene expression

    Author : Hamedeh Ghanaat-pour; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Hyperglycemia, deficient insulin secretion, and insulin resistance are the characteristic pathogenetic features of type 2 diabetes (T2D), hallmarked by functional and survival defects of the insulin-producing islet beta-cell. The primary pathogenesis of T2D probably involves both genetic and environmental forces, and hyperglycemia and very commonly hyperlipidemia might further aggravate beta-cell dysfunction. READ MORE

  7. 5. Preclinical investigation of novel therapies against neuroblastoma

    Author : Karin Hansson; Avdelningen för translationell cancerforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Neuroblastoma; Translational research; Preclinical drug evaluation;

    Abstract : Neuroblastoma is a childhood tumor of the sympathetic nervous system and the most common tumor form diagnosed in infants. Patients with aggressive tumors are treated intensely with multi-modal therapy including chemotherapy, surgery, radiotherapy and immunotherapy. READ MORE