Search for dissertations about: "PDZ"

Showing result 16 - 20 of 31 swedish dissertations containing the word PDZ.

  2. 16. Functional details of human HtrA2 protease studied by NMR spectroscopy

    Author : Emelie E. Aspholm; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; HtrA2; nuclear magnetic resonance; protein quality control; neurodegenerative disease; apoptosis;

    Abstract : Cells rely on an array of cellular machineries in the protein quality control system (PQC) to maintain the health of the collective proteome. The HtrA family of serine proteases are found in all kingdoms of life and function in the PQC by degrading damaged and aggregated proteins as well as by acting as molecular chaperones. READ MORE

  4. 17. The role of angiomotin in endothelial cell motility and cell-cell junction formation

    Author : Anders Bratt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Angiogenesis; cancer; angiostatin; angiomotin; cell motility cell-cell junction; tight junction; adherens junction;

    Abstract : Clinical as well as pre-clinical data show that tumor growth can be restrained by inhibiting angiogenesis. We have been investigating the mechanism of action of angiostatin, an inhibitor of angiogenesis, in order to design novel therapies against cancer. READ MORE

  5. 18. Organization of signaling networks during receptor-mediated membrane protein trafficking

    Author : Zongpei Chen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The mechanisms by which receptor signals are organized in a synergic/hierarchical manner in time and space during regulation of integral membrane protein traffic remain a present challenge. The aim of this study was to address some critical aspects of these processes. READ MORE

  6. 19. The Structural Modularity and Inherent Dynamics of the DegP Protease together with its Intertwined Role in the Bacterial Periplasm

    Author : Darios Šulskis; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; serine protease; DegP; nuclear magnetic resonance; E. coli; protein quality control; chaperone; HtrA;

    Abstract : The protein quality control machinery is a delicate and integrated network of molecular tools working together to fold or remove unwanted proteins from the cell. A distinct set of “gatekeepers” are involved in this process including molecular chaperones, proteases, oxidoreductases, transferases, and many others in both eukaryotic and prokaryotic organisms. READ MORE

  7. 20. Cytoskeletal Regulation During Embryonic Development in Drosophila melanogaster

    Author : Mojgan Padash; Udo Häckers grupp Utvecklingsbiologi i invertebrater; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Naturvetenskap; Natural science; DRhoGEF2; Actin cytoskeleton; Rho GTPase;

    Abstract : The development of multicellular organisms is associated with extensive rearrangements of cells and tissues. The driving force for these rearrangements is generated by the cell's actin cytoskeleton. During many morphogenetic processes dynamic rearrangement of the actin cytoskeleton is regulated by small GTPases of the Rho-family. READ MORE