Search for dissertations about: "PEG-lipid"

Showing result 1 - 5 of 6 swedish dissertations containing the word PEG-lipid.

  1. 1. Nanosized Bilayer Disks as Model Membranes for Interaction Studies

    Author : Anna Lundquist; Katarina Edwards; Marja-Liisa Riekkola; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; Disk; disc; lipid bilayer; PEG-lipid; model membrane; interaction; partitioning; drug; liposome; cryo-TEM; neutron scattering; capillary electrophoresis; immobilization; biosensor; membrane protein; melittin; Chemistry; Kemi;

    Abstract : PEG-lipid stabilized bilayer disks have been found in lipid mixtures containing polyethylene glycol (PEG)-lipids where the combination of a high bending rigidity and low PEG-lipid/lipid miscibility favours disk formation. The disks are planar and circular in shape and their long-term stability is excellent. READ MORE

  2. 2. Bilayer Discs - Fundamental Investigations and Applications of Nanosized Membrane Models

    Author : Emma Johansson; Katarina Edwards; Mats Almgren; Sven Engström; Uppsala universitet; []
    Keywords : Chemistry; disc; threadlike micelle; liposome; model membrane; drug partitioning; cryo-TEM; Kemi;

    Abstract : The bilayer disc is a flat, lipid aggregate structure in the nanometre regime. It is composed of a bilayer of amphiphilic molecules with micelle-forming amphiphilic molecules supporting the rim, which prevent disc fusion and self-closure. READ MORE

  3. 3. Regulation of thromboinflammation in therapeutic medicine : Special focus on surface coating strategies

    Author : Sana Asif; Bo Nilsson; Christine Skerka; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Biomaterials are an integral part of modern health care and offer potential treatment modalities to diseases and conditions otherwise intractable. However, the critical issue herein is incompatibility reactions. READ MORE

  4. 4. Physico-Chemical Investigations of Bilayer Discs and Related Lipid Structures Formed in Liposomal Systems Intended for Triggered Release

    Author : Maria Sandström; Katarina Edwards; Mats Almgren; Tommy Nylander; Uppsala universitet; []
    Keywords : Physical chemistry; liposome; triggered release; pH-sensitive liposomes; temperature-sensitive liposomes; drug partitioning; cryo-TEM; discs; Fysikalisk kemi;

    Abstract : This thesis describes results from fundamental studies of liposomes intended for drug delivery and pH or temperature triggered release. In addition, the effect of lipid composition on bilayer disc formation and a potential application of the bilayer discs were investigated. READ MORE

  5. 5. Development and Evaluation of Lipodisks Intended for Use as Biomimetic Membranes and Drug Carriers

    Author : Malin Morin Zetterberg; Katarina Edwards; Jonas Bergquist; Ana Maria Carmona-Ribeiro; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; model membranes; drug delivery; drug partitioning; antimicrobial peptides; nanocarriers; cryo-TEM; polymer-stabilized bilayer disks; Chemistry with specialization in Physical Chemistry; Kemi med inriktning mot fysikalisk kemi;

    Abstract : Polyethylene glycol-stabilized lipodisks have emerged as a novel type of lipid-based nanoparticles with high potential as both drug carriers and biomimetic membranes. In this thesis we assess both of these applications, and show how the properties of the lipodisks can be further developed and optimized. READ MORE