Search for dissertations about: "PGE2 and pain"

Showing result 1 - 5 of 17 swedish dissertations containing the words PGE2 and pain.

  1. 1. Molecular Mechanisms of Reward and Aversion

    Author : Anna Klawonn; David Engblom; Anders Blomqvist; Paul Kenny; Linköpings universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; Motivation; Dopamine; Reward; Aversion; Negative affect; Systemic Inflammation; Drug Addiction; Cytokines; Prostaglandin E2; Melanocortin receptor 4; Acetylcholine; Muscarinic M4 receptor;

    Abstract : Various molecular pathways in the brain shape our understanding of good and bad, as well as our motivation to seek and avoid such stimuli. This work evolves around how systemic inflammation causes aversion; and why general unpleasant states such as sickness, stress, pain and nausea are encoded by our brain as undesirable; and contrary to these questions, how drugs of abuse can subjugate the motivational neurocircuitry of the brain. READ MORE

  2. 2. Masseter muscle pain and its relation to pain mediators in fibromyalgia and local myalgia

    Author : Britt Hedenberg-Magnusson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Fibromyalgia; glucocorticoid; intramuscular temperature; isometric contraction; leukotriene B4; masseter muscle; microdialysis; myalgia; neuropeptide Y; pressure pain threshold; pressure pain tolerance level; prostaglandin E2; trapezius muscle; temporomandibular disorders; questionnaire; visual analogue pain scale.;

    Abstract : The aim of this investigation was to study chronic jaw muscle pain in fibromyalgia, local myalgia and healthy individuals in relation to the pain mediators PGE2, LTB4 and NPY and to study the effects of glucocorticoid administration and repetitive isometric contraction. A questionnaire showed presence of symptoms from the temporomandibular region in almost all fibromyalgia patients and the local pain was correlated to the general pain but on a lower level. READ MORE

  3. 3. Effects of low-load repetitive work and mental load on sensitising substances and metabolism in the trapezius muscle

    Author : Gerd Flodgren; Gisela Sjøgaard; Umeå universitet; []
    Keywords : work-related muscle pain; microdialysis; near-infrared spectroscopy; electromyography; glutamate; lactate; pyruvate; prostaglandin E2; norepinephrine; Occupational and Environmental Medicine; arbets- och miljömedicin;

    Abstract : Low-load repetitive work (LLRW) and mental load are important risk factors for the development of workrelated muscle pain. The link between these risk factors and the development of pain is still not understood, but stimulation of chemo-sensitive receptors in the muscle probably plays an important role. READ MORE

  4. 4. Microsomal prostaglandin E synthase 1 and microsomal glutathione transferase 1: inhibition and mechanism

    Author : Linda Spahiu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : The Membrane-Associated Proteins in Eicosanoid and Glutathione Metabolism (MAPEG) is a family of six membrane bound proteins with different biological functions. MAPEG superfamily members enable and catalyze reactions where reactive lipid intermediates are either transformed to physiological messengers or turned into unreactive compounds. READ MORE

  5. 5. Inflammation and wound healing following photorefractive keratectomy

    Author : Santiago Tomás Barberán; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Photorefractive keratectomy; excimer laser; inflammation; flare; prostaglandins; diclofenac; dexamethasone; pain; epithelial healing; corneal topography; growth factors; metalloproteinases; collagen; haze; haze distribution; Scheimpflug system; Laser Flare Meter; regression; reoperation; wound healing;

    Abstract : This study comprises different aspects on the inflammatory and wound healing responses of the eye after Photorefractive Keratectotmy (PRK). The purpose was to provide basic information about the inflammatory reaction and the wound healing after surgery. PRK is considered a good technique for surgical correction of and moderate myopia. READ MORE