Search for dissertations about: "PGE2 and pain"

Showing result 6 - 10 of 18 swedish dissertations containing the words PGE2 and pain.

  2. 6. Characterization of the PGE2 pathway in arthritis and inflammation : mPGES-1 as a therapeutic target

    Author : Patrick Leclerc; Karolinska Institutet; Karolinska Institutet; []
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    Abstract : The inducible prostaglandin (PG) E2 pathway is defined by the concerted activities of the enzymes cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase (mPGES)-1 in producing PGE2. PGE2 has pro-inflammatory and immunomodulatory functions and is involved in an array of diseases with an autoimmune and chronic inflammatory component, including rheumatoid arthritis (RA). READ MORE

  4. 7. Post-polio syndrome : analysis of inflammation and immune modulation

    Author : Eva Melin; Karolinska Institutet; Karolinska Institutet; []
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    Abstract : Poliomyelitis is a viral infection, which affects the anterior horn cells of the spinal cord leaving patients with different levels and distribution of muscle weakness and loss of, or decreased, function. This situation has previously been regarded as a stable condition. READ MORE

  5. 8. Structure and function of microsomal prostaglandin E synthase-1

    Author : Sven-Christian Pawelzik; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The glutathione-dependent enzyme microsomal prostaglandin E synthase-1 (MPGES1) plays a pivotal role in inflammatory diseases. MPGES1 is up-regulated by pro-inflammatory cytokines in concert with cyclooxygenase (COX) -2, and the concerted action of both enzymes leads to the production of induced prostaglandin E2 (PGE2), a potent lipid mediator of inflammation, pain, and fever. READ MORE

  6. 9. Studies on anti-inflammatory and vasoactive effects of mPGES-1 inhibition

    Author : Julia Steinmetz-Späh; Karolinska Institutet; Karolinska Institutet; []
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    Abstract : Inflammation is the basis for various serious illnesses such as rheumatic diseases, cardiovascular diseases, and cancer. Prostaglandin E2 (PGE2) is a pro-inflammatory lipid mediator produced by cyclooxygenases (COX1/2) and the microsomal prostaglandin E synthase 1 (mPGES-1). READ MORE

  7. 10. mPGES-1 : a key regulator of fever and neonatal respiratory depression

    Author : Sipra Saha; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Prostaglandins are potent lipid mediators, synthesized de novo from arachidonic acid (AA) upon cell activation. AA is oxidized by the cyclooxygenase isoenzymes (COX-1 and COX-2) to form PGH2, the common substrate for downstream enzymes involved in prostaglandin biosynthesis. READ MORE