Search for dissertations about: "PGRP"
Showing result 1 - 5 of 7 swedish dissertations containing the word PGRP.
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1. Peptidoglycan recognition proteins in Drosophila melanogaster
Abstract : The fruit fly Drosophila melanogaster is an excellent model organism to study the innate immune response, because insects and mammals share conserved features regarding the recognition and destruction of microorganisms and Drosophila is easily accessible to genetic manipulation. In my present study, I identified a new family of pattern recognition molecules for bacterial peptidoglycan in Drosophila, the Peptidoglycan Recognition Proteins (PGRP). READ MORE
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2. Peptidoglycan Recognition Proteins : Major Regulators of Drosophila Immunity
Abstract : All eukaryotic organisms have an innate immune system characterized by germ-line encoded receptors and effector molecules, which mediate detection and clearance of microbes such as bacteria, fungi, and parasites. VertebrateDrosophila as a genetically tractable organism with a This thesis concerns the peptidoglycan recognition protein (PGRP) gene family in the fruit fly. READ MORE
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3. Grainy head target genes in epithelial morphogenesis and wound healing
Abstract : grainy head (grh) genes encode a family of transcription factors conserved from fly to human. Drosophila grh is the founding member of this gene family and has multiple functions, including tracheal tube size control, epidermal barrier formation and reconstruction after wounding. READ MORE
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4. Peptidoglycan regulation of Drosophila immunity
Abstract : Innate immunity is an ancient defense system that distinguishes between self and non self and is present in both vertebrates and invertebrates. Peptidoglycan (PGN), a cell wall component shared by both gram-negative and gram-positive bacteria, is the major recognition molecule for the detection of bacteria in Drosophila. READ MORE
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5. Innate immune gene expression and function studied in insects and mammals
Abstract : Insects and mammals possess innate immune responses to effectively recognize and eliminate invading microorganisms. Insects, who share with mammals conserved molecules for immune defense, are good model systems for innate immunity studies. READ MORE