Search for dissertations about: "PHARMACY Toxicology"
Showing result 16 - 20 of 98 swedish dissertations containing the words PHARMACY Toxicology.
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16. Distribution and function of TRP ion channels in primary sensory neurons
Abstract : It is frequently argued that cannabinoids exert part of their analgesic and anti-inflammatory effects via activation of the cannabinoid CB1 receptor located on TRPV1-expressing primary sensory nerve fibres in peripheral tissues. However, we find no evidence of CB1 receptor immunoreactivity on nerve fibres in rat or mouse hindpaw skin and mesenteric artery. READ MORE
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17. Studies on the deposition, bioavailability and systemic activity of glucocorticoids in man
Abstract : The local deposition, pharmacokinetics, and systemic activity of inhaled and intranasal glucocorticosteroids in different formulations and devices(ICSs) has been investigated. After nasal administration of the ICS budesonide (Bud), the systemic availability (F) was found to be significantly higher from an aqueous pump spray and from the powder inhaler Turbuhaler, than from a pressurized metered dose inhaler (pMDI), and the uptake process was slower and less complete with the pMDI formulation. READ MORE
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18. Antidepressant drug effects in vivo: Focus on pharmacokinetic and pharmacodynamic responses in different experimental paradigms
Abstract : Pharmacokinetic and pharmacodynamic activities of the antidepressants venlafaxine (VEN) and citalopram (CIT) were investigated in the portacaval shunted (PCS) rat, a model of chronic hepatic encephalopathy (HE), and normal/control rats. The levels of VEN in serum and brain were higher in PCS rats than in controls after a single injection and chronic treatment with VEN (10 mg/kg). READ MORE
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19. Effects of organo-halogenated compounds on the thyroid hormone system in rodents
Abstract : .... READ MORE
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20. Adseverin – An Immune-Specific Target of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin
Abstract : The environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces thymus atrophy and immunosuppression in all animal species examined and these effects constitute a potential risk to humans. TCDD can via binding to the intracellular aryl hydrocarbon receptor (AhR), modulate transcription of a number of genes and the aim of this thesis has been to identify such genes, which may explain the mechanisms behind TCDD-mediated immunotoxicity. READ MORE