Search for dissertations about: "PHOSPHATE BACKBONE"

Showing result 1 - 5 of 14 swedish dissertations containing the words PHOSPHATE BACKBONE.

  2. 1. Gene therapy tools: oligonucleotides and peptides

    Author : Jonas Eriksson; Ülo Langel; Jens Kurreck; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Gene therapy; oligonucleotide; peptide; RNA-cleaving deoxyribozyme; deoxyribozyme; DNAzyme; cell-penetrating peptide; CPP; enzyme; enzyme kinetics; kinetic assay; assay; telomerase; telomerase inhibitor; imetelstat; GRN163L; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Genetic mutations can cause a wide range of diseases, e.g. cancer. Gene therapy has the potential to alleviate or even cure these diseases. READ MORE

  4. 2. Kinetic assays for RNA-cleaving deoxyribozymes and other nucleases

    Author : Jonas Eriksson; Ülo Langel; Pia Ädelroth; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : In this thesis two different assays for real-time RNA-cleaving deoxyribozyme and general nuclease kinetics are presented. Previous publications on nuclease kinetic assays have been riddled with drawbacks of labeling, discontinuity, cost etc. READ MORE

  5. 3. Understanding Defect Structures and Host-guest Interactions in Metal-organic Frameworks

    Author : Kang Zhengzhong; Yaoquan Tu; Lars Ojamäe; KTH; []
    Keywords : metal-organic framework; defects; host-guest; molecular dynamics simulation; Teoretisk kemi och biologi; Theoretical Chemistry and Biology;

    Abstract : Metal-organic frameworks (MOFs) represent a class of crystalline porous materials with prospective applications in molecular capture, separation, storage and catalysis. It has been discovered that there exist various structural defects in MOFs, which can have dramatic impact on their properties. READ MORE

  6. 4. Molecular dynamics of protein-nucleic acid complexes

    Author : Katarina Hart; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Nucleic acids are essential molecules when it comes to replication, transcription and translation of the genetic information and nearly all functions of nucleic acids are carried out in complex with proteins. The proteins need to be able to discriminate between different sites on the nucleic acids for correct binding. READ MORE

  7. 5. Studies on the Non-covalent Interactions (Stereoelectronics, Stacking and Hydrogen Bonding) in the Self-assembly of DNA and RNA

    Author : Parag Acharya; Jyoti Chattopadhyaya; Frank Seela; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bioorganic chemistry; nucleic acids; NMR; Stereoelectronic effects; Hydrogen Bonding; Stacking; Bioorganisk kemi; Bioorganic chemistry; Bioorganisk kemi;

    Abstract : This thesis is based on ten publications (Papers I-X). The phosphodiester backbone makes DNA or RNA to behave as polyelectrolyte, the pentose sugar gives the flexibility, and the aglycones promote the self-assembly or the ligand-binding process. READ MORE