Search for dissertations about: "PHOX2B"

Showing result 1 - 5 of 6 swedish dissertations containing the word PHOX2B.

  2. 1. Identification and characterization of candidate genes for neuroblastoma development

    Author : Cecilia Krona; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; cancer; tumor; child; embryonal; neural crest; neuroblastoma; chromosome 1; 1p36; mutation; expression; tumor suppressor gene; UBE4B; KIF1B; PGD; CORT; DFFA; PEX14; ICAT; CASP9; ENO1; MBP1; APITD1; PHOX2B;

    Abstract : Neuroblastoma (NB) is the most common tumor during infancy. It arises from undifferentiated cells in the sympathetic nervous system and is characterized by both clinical and genetic heterogeneity. One of the features of NBs with unfavorable outcome is loss on distal chromosome 1p. READ MORE

  4. 2. Spatial and temporal mechanisms of cell fate determination in the developing CNS

    Author : José Dias; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The generation of neural cell diversity in the developing central nervous system relies on mechanisms that provide spatial and temporal information to neural progenitor cells. The deployment of morphogen gradients is an important strategy to impart spatial information to the field of responding cells. READ MORE

  5. 3. The role of Nkx proteins neuronal and glial specification

    Author : Anna Vallstedt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : During development, different classes of neurons and glia are generated from proliferative progenitor cells lining the ventricles of the brain and the lumen of the spinal cord. A central issue in developmental neuroscience is to understand the mechanisms by which these cells are generated in space and over time. READ MORE

  6. 4. Survival and differentiation of central noradrenergic neurons

    Author : Pontus Holm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : About half of all central noradrenergic (NA) neurons reside in the locus coeruleus (LC). Projections from the LC reach target regions throughout the entire brain and regulate a variety of functions, such as mood, vigilance, arousal, sleep, attention and memory acquisition. READ MORE

  7. 5. Generation of cell diversity in the developing brainstem and its modeling in vitro

    Author : Mariya Kozhevnikova; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The intersection of spatial and temporal patterning programs underlies the formation of neural cell type diversity in the developing central nervous system (CNS). Deciphering the molecular mechanisms regulating positional and temporal patterning provides a basic framework for how the developing brain can be functionally assembled, and the growing knowledge about these patterning mechanisms offer a powerful tool to effectively control the differentiation of pluripotent stem cells (PSCs) into different neuronal subtypes of clinical importance. READ MORE