Search for dissertations about: "PIP2"

Found 5 swedish dissertations containing the word PIP2.

  2. 1. Regulation of Phospholipase C and Plasma Membrane Phosphatidylinositol 4,5-bisphosphate in Insulin-Secreting Cells

    Author : Sophia Thore; Anders Tengholm; Erik Gylfe; Peter Jones; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell biology; PLC; PIP2; insulin-secreting cell; Ca2 ; evanescent wave microscopy; phosphoinositide kinase; ATP ADP ratio; Cellbiologi; Cell biology; Cellbiologi;

    Abstract : The membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) is an important signaling molecule as substrate for the phospholipase C (PLC)-catalyzed formation of inositol 1,4,5-trisphosphate (IP3) and diacylglycerol, and by directly regulating e.g. ion-channels, the cytoskeleton and vesicle trafficking in various types of cells. READ MORE

  4. 2. Plant major intrinsic proteins - functional implications of expression and localisation studies

    Author : Laure Fraysse; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Plant biochemistry; immunolabelling; microarray; plasma membrane; aquaporins; plant; water; Växtbiokemi;

    Abstract : Plant water channels are members of the very old Major Intrinsic Protein (MIP) family, with representatives in bacteria, fungi, animals, and plants. The genome of the model plant Arabidopsis thaliana contains 35 MIP genes. READ MORE

  5. 3. Expression and Function of Human and Plant Aquaporins

    Author : Maria Agemark; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; aquaporin; water channel; overexpression; Pichia pastoris; AQP8; AQP5; SoPIP2; 1;

    Abstract : The aquaporins (AQPs) belong to a family of water permeable membrane channels found in virtually all living organisms. Thirteen isoforms of mammalian AQPs are found, whereas in Arabidopsis thaliana 35 genes encoding AQPs are found. The AQPs are distributed in different organs, cell types and in different subcellular membranes. READ MORE

  6. 4. The role of phosphatidylinositol 4-phosphate 5-kinase type І alpha (PIP5K1α) and utility of its inhibitor for targeting metastatic cancer

    Author : Martuza Sarwar; Malmö Experimentell cancerforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate Cancer; Breast cancer; Cancer therapy; PIP5K1A; PI3K AKT signal pathway; Kinase inhibitors;

    Abstract : Prostate cancer (PCa) is the most common cause of cancer-related death in men after lung cancer. Annually, more than 9000 new cases are diagnosed in Sweden and 2500 of them die each year. Metastatic prostate cancer can be treated with castration. READ MORE

  7. 5. Mechanoregulation of angiopoietin-like 4 in epithelial-mesenchymal transition and cancer metastasis

    Author : Zehuan Liao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The epithelial-mesenchymal transition (EMT) serves as a pivotal mechanism in the progression of metastatic cancer. However, current research, predominantly reliant on 2D monolayer cultures, inadequately replicates the intricate nature of a 3D tumor microenvironment. READ MORE