Search for dissertations about: "PKB"

Showing result 1 - 5 of 44 swedish dissertations containing the word PKB.

  1. 1. Adipocyte phosphatases and the antilipolytic action of insulin

    University dissertation from Svante Resjö, BMC, C11, SE-221 84 LUND, SWEDEN

    Author : Svante Resjö; [2002]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein phosphorylation; protein purification; adipose tissue; PP2A; protein phosphatase; PDE3B; phosphodiesterase 3B; Insulin signalling; antilipolysis; Klinisk biologi; Clinical biology; PKB; protein kinase B;

    Abstract : Adipose tissue is the main site of energy storage of the body and an important endocrine organ. Knowledge of the regulation of fat metabolism and the endocrine factors secreted by the adipocyte is crucial for the understanding of diseases such as obesity and diabetes. Insulin is the main antilipolytic hormone. READ MORE

  2. 2. Insulin Signalling and Regulation of Protein Kinase B in Adipocytes

    University dissertation from Olga Göransson

    Author : Olga Göransson; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; Endokrinologi; sekretion; diabetologi; secreting systems; Endocrinology; PDK1; PKB; diabetes; insulin; adipocyte;

    Abstract : Insulin resistance is a hallmark of type 2 diabetes, an increasingly common disorder. The cause of insulin resistance is supposedly failures in the processes used by insulin to signal to the interior of its target cells. These failing steps are still unknown, most probably because of incomplete knowledge of how the insulin signals are transmitted. READ MORE

  3. 3. Protein kinases in hormonal regulation of adipocyte metabolism

    University dissertation from Protein Phosphorylation, Faculty of Medicine

    Author : Christine Berggreen; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adipocyte; PKB; AMPK; SIK3; insulin; catecholamines; lipolysis; lipogenesis; glucose uptake; de novo fatty acid synthesis; A769662; Akti; cAMP;

    Abstract : Abstract Along with liver and muscle tissue, adipose tissue helps maintain normal levels of glucose and lipids in the blood and has a very important role when it comes to storing lipids that can provide whole-body energy. After a meal is ingested, adipocytes take up glucose from the circulation and use it as a substrate for synthesis of new fatty acids (FAs) in a process known as de novo fatty acid synthesis, as well as for synthesis of glycerol. READ MORE

  4. 4. Studies on Cell Injury Induced by Hypoxia-Reoxygenation and Oxidized Low Density Lipoprotein With Special Reference to the Protectiove Effect of Mixed Tocopherols, Omega-3 Fatty Acids and Transforming Growth Factor-beta1

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Hongjiang Chen; Uppsala universitet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Tocopherols; fish oil; TGF-β1; NOS; adhesion molecules; MMPs; PKB; MAPK; H-R; Ox-LDL; Myocytes; HCAECs; Medicin; MEDICINE Dermatology and venerology; clinical genetics; internal medicine; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

    Abstract : Hypoxia-reoxygenation (H-R) injury is an important clinical phenomenon in patients with coronary artery disease (CAD). Endothelial injury is a critical step in the initiation and progression of atherosclerosis. Therefore, endothelial and cardiomyocyte protection has been considered an effective step in prevention and treatment of CAD. READ MORE

  5. 5. The mechanism of integrin inactivation and cell signalling induced by c-erbB2, an oncogenic growth factor receptor

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Shahram Hedjazifar; Göteborgs universitet.; Gothenburg University.; [2006]

    Abstract : Overexpression of the oncogenic growth factor receptor, c-erbB2, is linked with poor prognosis in breast carcinomas and is used as a target for therapeutic strategies. To elucidate the mechanism underlying the tumorigenic action of an elevated c-erbB2 level, leading to homodimerization and activation, we have used an inducible system where a hybrid receptor consisting of the cytoplasmic and transmembrane domains of c-erbB2 fused to the extracellular domain of the trkA NGF receptor has been stably transfected into an immortalized mammary epithelial cell line. READ MORE