Search for dissertations about: "PKC"

Showing result 21 - 25 of 138 swedish dissertations containing the word PKC.

  2. 21. Regulation of survival and proliferation of human intestinal epithelial cells by leukotriene D4

    Author : Sailaja Paruchuri; Malmö Experimentell patologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rac; General pathology; pathological anatomy; Patologi allmän ; patologisk anatomi; PI3K; CREB; p90RSK; Erk-1 2; PKC; inflammation; migration apoptosis; proliferation; LTD4; cell survival;

    Abstract : The pro-inflammatory mediator, Leukotriene D4 (LTD4) is a product of arachidonic acid cascade and has been implicated in asthma and inflammatory bowel diseases. Prolonged inflammatory conditions like ulcerative colitis increases the risk for the development of cancer and the factors that induce the chronic immune response remain uncertain. READ MORE

  4. 22. Importance of MAPK and PKC in cerebrovascular endothelin receptor changes

    Author : Marie Henriksson; Lund Medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; farmakognosi; farmaci; toxikologi; toxicology; pharmacy; pharmacognosy; Pharmacological sciences; Kardiovaskulära systemet; Cardiovascular system; Fysiologi; Physiology; cerebral arteries; ischemia; receptors; endothelin; Farmakologi;

    Abstract : Endothelin is a vasoactive peptide that exerts its effect through two receptors; the endothelin type A (ETA) and type B (ETB) receptor. The contractile ETA receptor is localized on smooth muscle cells in the vascular wall, while the ETB receptors are mainly situated on endothelial cells, mediating vasodilatation. READ MORE

  5. 23. Ocular function and morphology in humans and rabbits exposed to vigabatrin medication

    Author : Ulrika Kjellström; Lund Oftalmologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vimentin; PKC-alpha; visual field defects; optical coherence tomography; full-field electroretinography; GABA; vigabatrin;

    Abstract : Vigabatrin is an antiepileptic drug that is known to cause visual field defects and retinal dysfunction measured by full-field electroretinography (ff-ERG). Underlying mechanisms have not yet been elucidated. READ MORE

  6. 24. Leishmania donovani Lipophosphoglycan : Modulation of Macrophage and Dendritic Cell Function

    Author : Katarina Tejle; Birgitta Rasmusson; Karl-Eric Magnusson; Olle Stendahl; Marita Troye-Blomberg; Linköpings universitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Lipophosphoglycan; Leishmania donovani; macrophage; actin; phagocytosis; PKC alpha; dendritic cell; Microbiology and immunology; Mikrobiologi och immunologi;

    Abstract : Leishmania donovani is a blood-borne tropicial parasite, which infects humans through bites by Phlebotomus sandflies. The parasite survives and multiplies inside macrophages in inner organs, and causes the deadly disease visceral leishmaniasis (Kala-Azar). READ MORE

  7. 25. The molecular features in PKC epsilon determining its neurite-inducing capacity

    Author : Mia Ling; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; neuroblastoma; neurite outgrowth; C1 domain; cancerology; cancer; onkologi; Cytologi; protein kinase C;

    Abstract : Protein kinase C (PKC) is a family of serine/threonine kinases which are subgrouped into classical (a, bI, bII, g), novel (d, e, h, q) and atypical (z, i/l) isoforms. It has been shown that PKCe induces neurite outgrowth in neuroblastoma cells and the effect is mediated via the regulatory domain. READ MORE