Search for dissertations about: "PKG"

Showing result 1 - 5 of 6 swedish dissertations containing the word PKG.

  2. 1. Genes and proteins controlled by cGMP-PKG during retinal degeneration

    Author : Jiaming Zhou; Lund Oftalmologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; retinal degeneration; cell death; cGMP-PKG; organotypic explant culture; RNA sequencing; mass spectrometry;

    Abstract : prevalence was reported as 1:3000-4000 worldwide, making it the main reason for blindness in the working population in industrial countries. The mutations of over 70 genes have been related to this genetic disorder, and there is generally no effective treatment, except for gene therapy for the RPE65 mutations. READ MORE

  4. 2. Regeneration of Peripheral Nerves. The role of protein kinases, with emphasis on neurotrophic factor stimulation

    Author : Peter Wiklund; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NT-4; NT-3; NGF; MAPK; PKG; PKA; PKC; nodose ganglion; DRG; conditioning effect; neurotrophic factors; protein kinases; peripheral; nerve regeneration; BDNF; GDNF; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Abstract : The purpose of this study was to investigate the role of protein kinases in peripheral nerve regeneration, with the use of dorsal root ganglia (DRG) and nodose ganglia explants from adult mice. The effects of neurotrophic factor stimulation and protein kinase inhibition were studied for long (days) and short term (minutes) effects. READ MORE

  5. 3. The potential role of retinal cGMP-interaction partners within the degeneration mechanism causing Retinitis Pigmentosa

    Author : Michel Rasmussen; Lund Oftalmologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Retinitis Pigmentosa; Photoreceptors; cGMP; cGMP-interactors; retinal degeneration; neuroprotection;

    Abstract : The eye disease Retinitis Pigmentosa (RP) represents a heterogeneous group of inherited retinal dystrophies, and it has been estimated that 1 in 3000 to 7000 people worldwide has the disease. The symptoms of RP are photoreceptor degeneration that leads to night blindness, followed by a decline in peripheral and central vision, and potential blindness. READ MORE

  6. 4. Cyclic nucleotide signalling in Alzheimer's disease postmortem brain

    Author : Willy Lokwa Bonkale; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The aim of this study was to determine the nature and significance of altered guanylyl cyclase (GC) and adenylyl cyclase (AC) signalling in Alzheimer's disease (AD) postmortem brain. Paper I describes a study of particulate and soluble GC activities in postmortem temporal cortex from a series of AD and matched control subjects. READ MORE

  7. 5. Studies on aquaporin 4 : a molecular determinant of brain water homeostasis

    Author : Eli Gunnarson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : A well controlled brain water homeostasis is of utmost importance for an appropriate control of neuronal activity. Astrocytes express the water channel aqauporin 4 (AQP4) and play a key role for the maintenance of brain water homeostasis. Brain edema is a result of perturbed water homeostasis and involves astrocyte swelling. READ MORE