Search for dissertations about: "PKR"

Showing result 1 - 5 of 7 swedish dissertations containing the word PKR.

  2. 1. Signal Transduction in Malignant Cells – Transformation, Activation and Differentiation

    Author : Karin Kårehed; Fredrik Öberg; Jan-Ingvar Jönsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular medicine; transformation; PDGF; PI3K; Rho-GTPase; U-937; FcγRI; macrophage; Stat1; PKR; NFκB; ATRA; differentiation; Molekylärmedicin; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; Pathology; Patologi;

    Abstract : All aspects of cell life are regulated by signal transduction mechanisms. This thesis describes the regulatory roles of a few key signal transduction molecules involved in three major biological responses. READ MORE

  4. 2. Interferon-alpha signaling and cell cycle regulation in neuroendocrine tumors of the digestive system

    Author : Yinghua Zhou; Uppsala universitet; []
    Keywords : Medical sciences; interferon-α; carcinoid tumors; interferon regulatory factor; p68; PKR; p21; p27; cell cycle; cyclin-dependent kinase; protein phosphorylation; protein trafficking; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Abstract : The prognosis for untreated carcinoid patients is poor and their quality of life is low. IFN-α treatment has shown a response rate of 50-80%, however, the antitumor mechanism has not been elucidated. READ MORE

  5. 3. Studies on rotavirus replication

    Author : Alexis Fuentes; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Biokemi; Biochemistry; Biokemi; molekylärbiologi; Molecular Biology;

    Abstract : Rotavirus is the leading cause of dehydrating diarrhea in infants and young children globally. In cells infected with rotavirus SA11 the synthesis of viral RNA and protein predominated already after a few hours. Cellular RNA remained intact, but viral mRNA was preferentially utilised for protein synthesis. READ MORE

  6. 4. METAL CARBONYL MEDIATED REACTIONS - APPLICATIONS IN THE SYNTHESIS OF POTENTIAL GALECTIN INHIBITORS

    Author : Nuria Parera Pera; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : AbstractThis work reports the development of an asymmetric version of the Nicholas reaction using monodentate phosphoramidites as ligands, which enables asymmetric synthesis from racemic starting material. In addition, we describe the application of metal carbonyl mediated reactions, such as the Pauson-Khand reaction (PKR) and reactions involving cationic iron carbonyl dienyl complexes, for the synthesis of potential galectin inhibitors, implicated in human inflammatory responses and various pathologies. READ MORE

  7. 5. Arthritogenecity of RNA and its degradation products

    Author : Fariba Zare; Göteborgs universitet; []
    Keywords : dsRNA; ssRNA; virus; arthritis; TLR3; IL-1R; IFNalpha beta receptor; plasminogen; tissue factor; uric acid; inflammation; arthritis; neutrophils;

    Abstract : Viral infections often lead to arthralgias and overt arthritic states. Expression of double stranded RNA (dsRNA) is a common feature of all viruses during their replication and it has been suggested that it is able to induce production of pro-inflammatory cytokines, e.g., interferon-alpha (IFN-alpha). READ MORE