Search for dissertations about: "PLAG1"

Showing result 1 - 5 of 7 swedish dissertations containing the word PLAG1.

  1. 1. Studies of PLAG1 and HMGIC fusion oncogenes in human tumors

    Author : Anna-Karin Ström; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : Pleomorphic adenoma; carcinoma ex pleomorphic adenoma; lipoblastoma; PLAG1; HMGIC; chromosome translocation; promoter swapping; fusion oncogene; gene amplification;

    Abstract : .... READ MORE

  2. 2. Studies of Fusion Oncogenes and Genomic Imbalances in Human Tumors

    Author : Fredrik Persson; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer genetics; fusion oncogene; gene amplification; array CGH; PLAG1; HMGA2; FGFR1; MDM2; pleomorphic adenoma; carcinoma ex pleomorphic adenoma; liposarcoma;

    Abstract : Cancer is a genetic disease caused by mutations and chromosome rearrangements affecting oncogenes and tumor suppressor genes in particular. Molecular analyses of recurrent translocations in hematological disorders, as well as in certain solid tumor types, have shown that they frequently result in fusion oncogenes. READ MORE

  3. 3. Transcriptomic and functional studies of fusion oncogene-driven salivary gland tumors

    Author : Maryam K. Afshari; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; fusion oncogene; MYB; NFIB; PLAG1; HMGA2; adenoid cystic carcinoma; pleomorphic adenoma; targeted therapy;

    Abstract : Fusion genes are potent oncogenic drivers resulting from exchange of regulatory/coding sequences between two genes. They were originally identified in leukemias but are now recognized as key oncogenic events also in many solid tumors, including salivary gland tumors (SGTs). READ MORE

  4. 4. Epigenetic mechanisms and regulatory aspects of human cancer and neural progenitor cells : implications for diagnosis and therapy

    Author : Monira Akhtar; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Epigenetic is defined as heritable modification or properties of the functional genome that are not directly embedded in the DNA sequence. Epigenetic changes include DNA methylation, histone modifications and RNA-mediated gene silencing. READ MORE

  5. 5. Bioinformatic screening for candidate mutations underlying phenotypic traits in domestic animals

    Author : Shumaila Sayyab; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : NATURVETENSKAP; LANTBRUKSVETENSKAPER; LANTBRUKSVETENSKAPER; NATURAL SCIENCES; AGRICULTURAL SCIENCES; AGRICULTURAL SCIENCES;

    Abstract : Domestic animals represent excellent model organisms for gene mapping and identification of mutations underlying phenotypic traits. Humans have selected spontaneous mutations in farm and companion animals since they were domesticated and this has resulted in large phenotypic variation among different breeds. READ MORE