Advanced search

Showing result 1 - 5 of 141 swedish dissertations matching the above criteria.

2. 1. Analysis of Metabolites in Complex Biological Samples Using LC/MS and Multivariate Data Analysis : Metabolic Fingerprinting and Detection of Biomarkers

   Author : Helena Idborg; Sven Jacobsson; Per-Olof Edlund; Jonas Bergquist; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Metabolomics; Metabonomics; Metabolic Fingerprinting; Drug Metabolism; Biomarkers; Human Plasma; Rat Urine; LC MS; ZIC-HILIC; UPLC; UHPLC; ToF; Curve Resolution; Peak Detection; Pattern Recognition; Classification; PCA; PLS; PARAFAC; N-PLS; Data Fusion; Hierarchical Modeling; Batch modeling; Data Concatenation; Breast Cancer; Phospholipidosis; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

   Abstract : To facilitate early diagnosis of diseases and elucidation of the processes involved in their development and progression, various specific compounds or ‘biomarkers’ are often monitored. The first step is to decide which compounds to analyze. READ MORE

4. 2. Chemometric and signal processing methods for real time monitoring and modeling : applications in the pulp and paper industry

   Author : Anders Björk; Lars-Göran Danielsson; Guy Dumont; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Acoustic; Vibration; Multivariate; Chemometrics; PLS; OSC; PCA; FFT; Wavelets; WT-MRS; CWT-FLE; Pulp Quality; CSF; Brightness; Tensile Strength properties; Optical Properties; Measurement Technology; On-line; Non-invasive; Process Control; Process Analysis; Process Analytical Technology; PAT.; Akustik; Vibrationer; Multivariat; Kemometri; PLS; OSC; PCA; FFT; Wavelets; WT-MRS; CWT-FLE; Massakvalitet; CSF; Ljushet; Dragstyrkeegenskaper; Optiska egenskaper; Mätteknik; On-line; Icke berörande mätning; Processtyrning; Processanalys; Processanalytisk Teknologi; PAT.; Analytical chemistry; Analytisk kemi;

   Abstract : In the production of paper, the quality of the pulp is an important factor both for the productivity and for the final quality. Reliable real-time measurements of pulp quality are therefore needed. READ MORE

5. 3. Chemoinformetics for green chemistry

   Author : Tao Liu; Tomas Öberg; Ian Nicholls; Bert van Bavel; Linnéuniversitetet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; QSPR; PLS; Chemometrics; Chemoinformatics; Environmental chemistry; Miljökemi; Environmental Chemistry; Miljökemi;

   Abstract : This thesis focuses on the development of quantitative structure-activity relationship (QSPR) models for physicochemical properties, e.g., vapor pressure and partitioning coefficients. Such models can be used to estimate environmental distribution and transformation of the pollutants or to characterize solvents properties. READ MORE

6. 4. A multivariate approach to computational molecular biology

   Author : Fredrik Pettersson; Michael Sjöström; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; PLS; PCA; biomarker; Drosophila; SNP; linkage; disequilibrium; bioinformatics; computational; molecular; biology; genomics; microarray; SELDI; proteomics; Bioinformatics; Bioinformatik;

   Abstract : This thesis describes the application of multivariate methods in analyses of genomic DNA sequences, gene expression and protein synthesis, which represent each of the steps in the central dogma of biology. The recent finalisation of large sequencing projects has given us a definable core of genetic data and large-scale methods for the dynamic quantification of gene expression and protein synthesis. READ MORE

7. 5. Chemometrics : Unravelling information from complex data generated by modern instruments

   Author : Pedro F. M. de Sousa; Magnus Åberg; Johan Trygg; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemometrics; Chromatography; Mass spectrometry; DIA; PCA; PLS; Experimental Design; DNA; adductomics; Analytical Chemistry; analytisk kemi;

   Abstract : Chemometrics is a discipline dedicated to solving problems arising from complicated analytical systems, combining statistics, mathematics, and computational programming languages.This thesis is based on the work developed in four scientific projects published as papers in scientific journals. READ MORE