Search for dissertations about: "PNET"

Showing result 1 - 5 of 8 swedish dissertations containing the word PNET.

2. 1. The MEN 1 Pancreas : Tumor Development and Haploinsufficiency

   Author : Margareta Halin Lejonklou; Britt Skogseid; Peter Stålberg; Andreea Barbu; Gerard Doherty; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEN 1; PNET; tumor development; haploinsufficiency; survivin; Endokrinologi och Diabetologi; Endocrinology and Diabetology;

   Abstract : Multiple Endocrine Neoplasia Type I Syndrome (MEN 1) is a monogenic autosomal dominantly inherited cancer syndrome caused by a heterozygous loss of the MEN1 gene, predisposing for endocrine cell proliferation and tumor formation. MEN 1 carriers classically develop tumors in endocrine organs; the parathyroids, the endocrine pancreas, and the pituitary. READ MORE

4. 2. Aspects of MEN1 Tumorigenesis in Endocrine Pancreas and Adrenal Glands

   Author : Xia Chu; Kjell Öberg; Barbro Eriksson; Magnus Kjellman; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEN1; tumorigenesis; PNET; angiogenesis; adrenal glands; proteomic analysis; miRNA expression; Oncology; Onkologi;

   Abstract : Multiple endocrine neoplasia syndrome type 1 (MEN1) is an autosomal dominantly inherited disease, which is described as an association of tumors mainly in endocrine organs, including pancreas and adrenal glands. Pancreatic neuroendocrine tumors (PNETs) are the most common cause of death in MEN1 patients. READ MORE

5. 3. Brain tumors in children - National population-based studies on classification, diagnostics and long-term follow-up

   Author : Elizabeth Schepke; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pediatric CNS tumors; population-based; DNA methylation; profiling; CNS-PNET; re-evaluation; incidence rate; long-term outcome; classification; Pediatric CNS tumors; Population-based; DNA methylation; Profiling; CNS-PNET; Re-evaluation; Incidence rate; Long-term outcome; Classification;

   Abstract : Although the prognosis for pediatric tumors of the central nervous system (CNS) has improved over time it is urgent to reduce mortality and improve long-term quality of life for survivors. With this aim, the first step is to identify the correct diagnosis in order to choose the right therapy and avoid unnecessary treatment. READ MORE

6. 4. Detection of fusion genes and fusion proteins in sarcoma : methodological and clinical aspects

   Author : Gunnar Nilsson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Ewing s sarcoma; synovial sarcoma; translocation; fusion gene; fusion protein; diagnosis and prognosis;

   Abstract : Ewing's sarcoma/PNET and synovial sarcoma, all regarded as high-grade tumours, have their peak incidence during the second decade of life, thus affecting children and adolescents. Both tumour types have specific chromosomal translocations, i.e. t(11;22) and t(X;18), respectively, resulting in fusion genes coding for chimeric proteins. READ MORE

7. 5. The Role of SOX9 in Medulloblastoma

   Author : Vasil Savov; Fredrik Swartling; Ulrich Schüller; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medulloblastoma; SOX9; MYCN; cancer development; recurrence; regulation; tumor metastasis; migration; Medical Science; Medicinsk vetenskap;

   Abstract : Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Overall survival is about 70% and in cases where current treatment fails, the disease recurs and most often is fatal. At the molecular level, MB can be divided into four defined subgroups: WNT, SHH, Group 3 and Group 4. READ MORE