Search for dissertations about: "POLRMT"

Showing result 1 - 5 of 7 swedish dissertations containing the word POLRMT.

  2. 1. Pathogenic mechanisms affecting mitochondrial DNA replication and transcription

    Author : Meenakshi Singh; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; mtDNA; ribonucleotides; nucleoside analogues; POLRMT;

    Abstract : Mitochondria are cytoplasmic organelles fundamental to life and health. In mitochondria, energy from the food we eat is converted into adenosine triphosphate (ATP), which in turn is used as a source of chemical energy to drive a multitude of cellular reactions. READ MORE

  4. 2. Molecular mechanisms for transcription in mammalian mitochondria

    Author : Martina Gaspari; Karolinska Institutet; Karolinska Institutet; []
    Keywords : mitochondria; oxidative phosphorylation; mtDNA; transcription; TFAM; TFB1M TFB2M; POLRMT; promoter recognition; CSB II;

    Abstract : The circular double stranded mitochondrial genome (mtDNA), which is about 16,600 bp in humans and 16,300 bp in mice, encodes 13 of the -90 different proteins present in the respiratory chain of mammalian mitochondria. The remaining components of the respiratory chain are encoded by nuclear genes and imported into the mitochondrial network. READ MORE

  5. 3. Structural-functional studies of mitochondrial matrix proteins

    Author : Saba Shahzad; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Mitochondria;

    Abstract : The mitochondrion is the powerhouse of the eukaryotic cell. Most of the energy required to carry out cellular processes is generated inside mitochondria via the process of oxidative phosphorylation. The machinery required for oxidative phosphorylation is encoded by both the nuclear and the mitochondrial genome. READ MORE

  6. 4. Molecular insights into mitochondrial DNA replication

    Author : Javier Miralles Fusté; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mitochondria are organelles found in eukaryotic cells. These organelles produce most of the adenosine triphosphate that cells use as a source of energy. Mitochondria contain their own genomic material, a circular DNA genome (mtDNA) that encodes subunits of the respiratory chain complexes and RNA components needed for mitochondrial translation. READ MORE

  7. 5. Linking transcription to DNA replication in mammalian mitochondria

    Author : Yonghong Shi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Most of the adenosine phosphate (ATP) used to drive cellular processes is produced through oxidative phosphorylation (OXPHOS). At the heart of this process is the electron transport chain, which contains a number of protein complexes located in the inner membrane of mitochondria. READ MORE