Search for dissertations about: "PON1"

Found 5 swedish dissertations containing the word PON1.

  2. 1. Computational Modeling of the Mechanisms and Selectivity of Organophosphate Hydrolases

    Author : Miha Purg; Shina C. Lynn Kamerlin; Iñaki Tuñón; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Organophosphate Hydrolase; Computational enzymology; MPH; DFPase; PON1; Empirical Valence Bond; EVB;

    Abstract : Computational modeling is becoming an increasingly integral part of (bio)chemistry, providing a powerful complementary view into the dynamics, binding, and reactivity of biochemical systems. In particular, molecular simulations based on multiscale models are now regularly employed in studies of enzymatic reactions, offering invaluable mechanistic insight through the lens of molecular energy landscapes. READ MORE

  4. 2. Computational Protein Evolution : Modeling the Selectivity and Promiscuity of Engineered Enzymes

    Author : Klaudia Szeler; Shina C. Lynn Kamerlin; Mikael Widersten; Maria Ramos; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; enzymes; kinetics; catalysis; density functional theory; empirical valence bond; diesters; evolution; promiscuity; Biokemi; Biochemistry;

    Abstract : Enzymes are biological catalysts that significantly increase the rate of all biochemical reactions that take place within cells and are essential to maintain life. Many questions regarding their function remain unknown. READ MORE

  5. 3. Genes involved in Parkinson's disease : focus on mitochondrial and detoxifying enzymes

    Author : Anna Anvret; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Parkinson's disease is a common progressive neurodegenerative disorder which mostly affects the elderly population, with a prevalence of more than 1.5% in the population over the age of 65 years. Clinical motor symptoms are mainly caused by degeneration of dopamine neurons in substantia nigra pars compacta. READ MORE

  6. 4. On Parkinson's disease and schizophrenia : case control studies, cellular localization and modelling of candidate genes

    Author : Andrea Carmine; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Genetic; association; dopamine; Parkinson s disease; schizophrenia; retinoid; aldehyde; toxicity;

    Abstract : The causes of many major neurodegenerative, neurodevelopmental and psychiatric diseases are unknown. This thesis has aimed at applying knowledge about the dopamine (DA) neuron system and other key systems to clinical material (DNA and post mortem brain tissue) collected from patients with Parkinson s disease (PD), schizophrenia (SZ) and controls, in order to decipher genetic risk factors. READ MORE

  7. 5. On genes involved in common neurological disorders : focus on Parkinson's disease

    Author : Caroline Ran; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Parkinson’s disease and migraine are complex neurological disorders and it is likely that a combination of genetic risk factors are involved in the etiology of both these diseases. Papers in this thesis investigate candidate genes in the search of genetic risk factors contributing to disease. READ MORE