Search for dissertations about: "PPARγ"

Showing result 1 - 5 of 20 swedish dissertations containing the word PPARγ.

  2. 1. Role of nuclear receptors in the regulation of human adipose tissue metabolism

    Author : Prasad G. Kamble; Jan W Eriksson; Ingrid Dahlman; Uppsala universitet; []
    Keywords : human adipose tissue; nuclear receptors; glucocorticoids; estrogen; PPARγ; lipocalin 2; glucose uptake; lipolysis; adipogenesis; genotype-based recall;

    Abstract : Nuclear receptors modulate expression of genes involved in adipose tissue (AT) metabolism. Their improved understanding may provide new treatment options for metabolic disorders such as obesity, insulin resistance (IR) and type 2 diabetes (T2D). READ MORE

  4. 2. WISP-2 - A Novel Adipokine Related to Obesity and Insulin resistance

    Author : John Grünberg; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adipose tissue; BMP4; Canonical WNT pathway; Insulin Resistance; Obesity; PPARγ; Type 2 Diabetes; WISP2;

    Abstract : Type 2 diabetes mellitus (T2D) is increasing worldwide at an epidemic rate and is expected to reach 592 million inflicted individuals by 2035 as compared to 382 million in 2013. Obesity is a major risk factor for insulin resistance, defined as an impaired cellular effect of insulin, and this precedes the development of T2D. READ MORE

  5. 3. Transcriptional activity of PPARγ in primary human adipocytes

    Author : Lilian Sauma; Fredrik Nyström; Mats Söderström; Jan Eriksson; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : The prevalence of obesity is increasing in most parts of the world and is a strong risk factor for the development of insulin resistance, type 2 diabetes and hypertension. Adipose tissue is mainly composed of adipocytes which store energy in the form of triglycerides and release it as free fatty acids. READ MORE

  6. 4. Tissue- and site-specific effects of PPARγ activation and its role in chronic inflammation

    Author : Sebastian Pott; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Developmental programming, metabolism, immune function and tissue homeostasis in multicellular organisms are regulated by a plethora of stimuli. Transcription factors (TFs) convert incoming signals to appropriate transcriptional responses of the genome. READ MORE

  7. 5. The microbiome, PPARγ and AhR in the inflammation-metabolism interface within the gastrointestinal tract

    Author : Agata Korecka; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The mammalian body is a mosaic of different organisms - a holobiont, which contains all the biomolecules and their metabolites encoded in our eukaryotic genome and supplemented by an even larger pool of prokaryotic genes and products. This symbiotic coexistence is presumed to have evolved to necessitate the sharing of biological and biochemical needs important for growth, body physiology, survival and reproduction. READ MORE