Search for dissertations about: "PPARgamma2"

Found 3 swedish dissertations containing the word PPARgamma2.

  2. 1. PPARs in the regulation of gene expression and lipid metabolism in the liver

    Author : Ulrika Edvardsson; Göteborgs universitet; []
    Keywords : PPARalpha; PPARgamma; PPARgamma2; Wy14; 643; rosiglitazone; liver; hepatocytes; insulin; fatty acids; MTP; ADRP; lipid metabolism; apoB; triglycerides.;

    Abstract : Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors, regulating genes involved in carbohydrate, lipid and lipoprotein metabolism. Synthetic PPARalpha agonists used in clinic are the fibrates, and their hypotriglyceridemic effect is believed to be the result of decreased VLDL triglyceride secretion and increased turnover of triglyceride-rich lipoprotein particles in the circulation. READ MORE

  4. 2. Effects of cytokines on preadipocyte differentiation and Wnt signalling

    Author : Birgit Gustafson; Göteborgs universitet; []
    Keywords : adipocyte differentiation; adiponectin; beta-Catenin; C EBPalpha; IL-6; PPARgamma; TNFalpha; Wnt signalling;

    Abstract : The relationship between amount of adipose tissue, the Metabolic Syndrome and Type 2 diabetes has been recognized for several years. However, the mechanisms for this remain to be clarified. Not all obese individuals develop insulin resistance or Type 2 diabetes and these perturbations are also seen in non-obese individuals. READ MORE

  5. 3. The role of PPARalpha and growth hormone in hepatic lipid metaboism and atherosclerosis

    Author : Anna Ljungberg; Göteborgs universitet; []
    Keywords : growth hormone; PPARalpha; atherosclerosis; lipid metabolism; fatty acids; apoB; ; ADRP; triglycerides; PGC-1; liver;

    Abstract : Dyslipidemia mainly results from oversecretion of apoB-containing lipoproteins from theliver and is one of the most important risk factors for the development of atherosclerosis.Growth hormone (GH) plays a key role in the regulation of lipoprotein metabolism and thus,disturbances in GH secretion are associated with dyslipidemia and cardiovascular disease. READ MORE