Search for dissertations about: "PR isoforms"

Found 4 swedish dissertations containing the words PR isoforms.

  2. 1. Expression, regulation and fuction of small ubiquitin-related modifier-1. Interaction with nuclear proteins in vivo

    Author : Linus Ruijin Shao; Göteborgs universitet; []
    Keywords : SUMO-1; LH receptor; PR isoforms; caspase-3; DNA fragmentation; apoptosis; granulosa cells; HIF-1alpha; hypoxia; brain and heart;

    Abstract : The small ubiquitin-related modifier-1 (SUMO-1) is a 101-amino acid, ~12 kDa protein that is 18% identical to ubiquitin. Posttranslational covalent tagging of proteins with SUMO-1 (SUMOylation) serves many functions. For example, regulation of protein stability and modulation of transcriptional activation. READ MORE

  4. 2. Studies on the extracellular matrix of the dysfunctional pelvic floor

    Author : Marie Westergren Söderberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Pelvic floor; pelvic organ prolapse; stress urinary incontinence; extracellular matrix; collagen; SLRPs; decorin; lumican; fibromodulin; elastin associated proteins; fibrillin-1; fibulin-5; sex steroid hormone receptors; ER; PR; AR;

    Abstract : Objective: Pelvic floor dysfunction cause impaired quality of life of many women and is one of the most common reasons for gynaecological surgery on benign indications. Little is known about the pelvic floor extracellular matrix as a pre-requisite for mechanical sustainability through vaginal delivery, age and hormonal changes. READ MORE

  5. 3. Histone modification regulated bysuppressor of Zeste 12 and Ipl1 : Aurora-like kinase in Drosophila

    Author : Anna Larsson; Umeå universitet; []
    Keywords : molekylär bioteknik inst f molekylärbiologi ; molecular biotechnology dept of molecular biology ;

    Abstract : Polycomb group (PcG) proteins are a group of genome wide silencers that are crucial for many processes during the development. In Drosophila PcG proteins are organised into four different complexes: PRC1, PRC2, PhoRC and PR-DUB. PRC2 consists of four core proteins: Su(z)12, E(z), Esc and Nurf. READ MORE

  6. 4. MicroRNAs in HER2-Amplified Breast Cancer

    Author : Inga Newie; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; miR-21; PAPD5; Breast Cancer; miR-4728; microRNA; ERBB2 HER2;

    Abstract : Background: Breast cancer is the most common female malignancy and the leading cause of cancer-related deaths worldwide. Targeted therapy against the main biomarkers estrogen receptor alpha (ER) and human epidermal growth factor receptor 2 (HER2/ERBB2) have greatly improved mortality rates, but ab initio or acquired therapy resistance is common. READ MORE