Search for dissertations about: "PRIMATE MODEL"

Showing result 1 - 5 of 35 swedish dissertations containing the words PRIMATE MODEL.

  2. 1. A primate model for acute dystonia and tardive dyskinesia : development, validation and application

    Author : Sven Bárány; Uppsala universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : .... READ MORE

  4. 2. The non-human primate as a model of human parkinsonism

    Author : Alison McCormack; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Parkinson s disease; substantia nigra; aging; neuromelanin; MPTP; alpha-synuclein; levodopa; dyskinesia; methamphetamine;

    Abstract : The motor deficits seen in Parkinson’s disease (PD) are the result of a loss of catecholaminergic neurons from the substantia nigra (SN) and the associated loss of striatal dopamine. Clinical signs become evident once striatal dopamine levels decline by at least 70-80% and nigral cell numbers by 40%, and worsen with increased duration of the disease. READ MORE

  5. 3. Receptor use of primate lentiviruses

    Author : Dalma Vödrös; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV; SIV; animal models; receptor use; neutralizing antibodies; CD4-independence;

    Abstract : Human and simian immunodeficiency viruses (HIV and SIV) enter target cells using CD4, the primary cell surface receptor and a secondary receptor, called coreceptor. Coreceptor use of HIV can be related to other biological features of the virus and to the severity of infection as well. READ MORE

  6. 4. Studies of Innate and Adaptive Immunity in Islet Transplantation

    Author : Maria Hårdstedt; Olle Korsgren; Bo Nilsson; Thierry Berney; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetes; islet transplantation; islets of Langerhans; xenotransplantation; nonhuman primate; blood; whole blood model; innate immunity; adaptive immunity; IBMIR; chemokines;

    Abstract : Clinical islet transplantation is today an established alternative treatment for a selected group of type 1 diabetes patients. The predominant technique for transplantation is infusion of islets in the liver via the portal vein. READ MORE

  7. 5. Involvement of non-dopaminergic systems in L-DOPA-induced dyskinsia

    Author : Daniella Rylander; Basala gangliernas patofysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease; Dyskinesia; L-DOPA; 6-OHDA rat model; MPTP monkey model; glutamate; serotonin; DA.; 5-HT;

    Abstract : Parkinson's disease and L-DOPA-induced dyskinesia (LID) does not merely involve the dopamine (DA) system but also include non-dopaminergic systems such as glutamate and serotonin (5-HT). An aberrant glutamate transmission at the corticostriatal synapse, has been linked to LID. READ MORE