Search for dissertations about: "PRRT"

Showing result 1 - 5 of 16 swedish dissertations containing the word PRRT.

  2. 1. Monitoring of neuroendocrine tumor patients undergoing systemic therapies

    Author : Olof Pettersson; Anders Sundin; Håkan Geijer; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Therapy monitoring; NET; neuroendocrine tumor; computed tomography; CT; PRRT; 177Lu-DOTATATE; TGR; tumor growth rate; theranostics; DOTATOC-PET CT; Radiology; Radiologi; Endokrinologi och Diabetologi; Endocrinology and Diabetology; Oncology; Onkologi;

    Abstract : Monitoring of neuroendocrine tumor (NET) patients undergoing systemic therapies is troublesome as biomarkers capable of detecting tumor responses have been difficult to establish. Changes in the sum of target lesion diameters are used to evaluate the effects of therapy according to the response evaluation criteria in solid tumors (RECIST 1.1). READ MORE

  4. 2. Theranostics in Neuroendocrine Tumors : Somatostatin Receptor Imaging and Therapy

    Author : Ezgi Ilan; Mark Lubberink; Peter Bernhardt; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 177Lu-DOTATATE; 68Ga-DOTATATE; 68Ga-DOTATOC; PRRT; Theranostics; PET CT; SPECT CT; Neuroendocrine tumors; Somatostatin receptors; Medicinsk radiofysik; Medical Radiophysics;

    Abstract : Neuroendocrine tumors (NETs) are characterized by cellular overexpression of somatostatin receptors (SSTR), which allows for the use of radiolabeled somatostatin analogs (SSA) for both imaging and therapy. Because NETs often are diagnosed at a metastatic stage, curative surgery is not possible. READ MORE

  5. 3. Nuclear medicine imaging and treatment in pheochromocytoma, paraganglioma, and role of the new tracer 11C-hydroxy ephedrine in diabetes mellitus

    Author : Achyut Ram Vyakaranam; Anders Sundin; Elin Trägårdh; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 11C-HED; PRRT; TCTTV; Non-Invasive imaging; symapthetic innervation; pheochromocytoma; paraganglioma; NETs; RECIST 1.1; Oncology; Onkologi; Endokrinologi och Diabetologi; Endocrinology and Diabetology;

    Abstract : Carbon-11 hydroxy ephedrine (11C-HED) is a norepinephrine analog which binds to the norepinephrine receptor present in adrenal medulla, lung, liver and pancreas. 11C-HED-positron emission tomography with concomitant computed tomography (PET/CT) can image these organs. READ MORE

  6. 4. Small-scale dosimetry methods for normal tissues after radioembolization and peptide receptor radiotherapies; a focus on the liver parenchyma and the bone marrow

    Author : Jens Hemmingsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dosimetry; Radioembolization; PRRT; lutetium-177; terbium-161; yttrium-90;

    Abstract : Radionuclide therapies are increasingly used in cancer treatments as they have been proven to be both effective and safe. As biodistributions and uptake vary widely between patients, a standardized approach is bound to leave a fraction of patients overtreated or undertreated. READ MORE

  7. 5. lmprovement of 177Lu-octreotate treatment of small-intestine neuroendocrine tumors by hyperfractionation

    Author : Mikael Elvborn; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Peptide receptor radionuclide therapy; PRRT; somatostatin receptor; SSTR; apoptosis; gene expression; epigenetic effects;

    Abstract : Neuroendocrine tumor incidence is steadily rising, and the late diagnosis often results in metastatic disease and current treatments mostly prolong life and in-crease quality of life without increasing cure rate. 177Lu-octreotate was recently approved for treatment of neuroendocrine tumors, but the dosage scheme should be optimized. READ MORE