Search for dissertations about: "PSD-95"

Showing result 1 - 5 of 11 swedish dissertations containing the word PSD-95.

  2. 1. Exploring the Role of the PDZ Domain in a Supramodule

    Author : Louise Laursen; Per Jemth; Per Hammarström; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; PSD-95; PSG; PDZ3; supramodule; liquid liquid phase separation; allostery; folding; binding; evolution; post synaptic density; SynGap; CRIPT; AGRB1; Medical Biochemistry; Medicinsk biokemi; Medical Biochemistry; Medicinsk biokemi;

    Abstract : The postsynaptic density (PSD) is a large, dense and membraneless compartment of proteins associated below the postsynaptic membrane bilayer, and which constantly undergoes morphological alteration in response to synaptic activity. Formation of PSD is associated with liquid-liquid phase separation of scaffold proteins in complex with other PSD proteins. READ MORE

  4. 2. Megalin, an Endocytotic Receptor with Signalling Potential

    Author : Mårten Larsson; Lars Rask; Bo Åkerström; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Megalin; LRP-2; Postsynaptic density-95; Retinol-binding protein; Oligodendrocytes; Central nervous system; Biokemi; Biochemistry; Biokemi;

    Abstract : Megalin is an endocytotic receptor belonging to the low-density lipoprotein family. It has often been viewed only as merely a scavenger receptor of absorptive and secretory epithelia. Recent work has revealed that the megalin intracellular domain contains several motifs potentially binding proteins involved in signal transduction. READ MORE

  5. 3. Post-synaptic Density Disc Large Zo-1 (PDZ) Domains : From Folding and Binding to Drug Targeting

    Author : Celestine Chi; Per Jemth; Maria Selmer; Sarah Linse; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein-protein interaction; protein folding; and drug design; Biochemistry; Biokemi; Biokemi; Biochemistry;

    Abstract : Understanding how proteins fold and bind is interesting since these processes are central to most biological activity. Protein folding and protein-protein interaction are by themselves very complex but using a good and robust system to study them could ease some of the hurdles. READ MORE

  6. 4. Studies on the plasticity of glutamate receptors and its role for neuronal calcium homeostasis

    Author : Linda Westin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Calcium is the most important and versatile signaling molecule in the brain. Neurons are equipped with a variety of tools to utilize this simple ion in diverse ways. From controlling the millisecond fast neurotransmitter release, to reshaping neuronal structure and function. READ MORE

  7. 5. Mediators of synaptic activity in anxiety- and depression-related behaviors

    Author : Carly Kiselycznyk; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Depression and anxiety are leading causes of years lost to disability, despite antidepressants being among the most commonly prescribed medications. Most currently prescribed antidepressants were found serendipitously rather than from an understanding of the biological mechanisms underlying depression. READ MORE