Search for dissertations about: "PTMs"

Showing result 1 - 5 of 21 swedish dissertations containing the word PTMs.

  1. 1. Building a map of the breast cancer proteome - Strategies to increase coverage

    Author : Paolo Cifani; Lund University.; Lunds universitet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Quantitative proteomics; Mass-Spectrometry; Cancer; DNA repair; Hypoxia; PTMs; Sample fractionation; Database;

    Abstract : Amongst the various –omics sciences, proteomics has the highest potential for functional characterization and consequently can contribute significantly to the field of cancer research. In particular, the focus of this thesis is on breast cancer. READ MORE

  2. 2. From Physicochemical Features to Interdependency Networks A Monte Carlo Approach to Modeling HIV-1 Resistome and Post-translational Modifications

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Marcin Kierczak; Uppsala universitet.; [2009]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; HIV-1; resistome analysis; drug resistance; predicting PTMs; molecular interdependency networks; MCFS-ID; feature selection; interactome; machine-learning; rough sets; TECHNOLOGY Bioengineering Bioinformatics; TEKNIKVETENSKAP Bioteknik Bioinformatik; Computer Science; datavetenskap; Biology; with specialization in structural biology; biologi; med inriktning mot strukturbiologi;

    Abstract : The availability of new technologies supplied life scientists with large amounts of experimental data. The data sets are large not only in terms of the number of observations, but also in terms of the number of recorded features. READ MORE

  3. 3. Post-translational modifications of proteins in human breast cancer: proteomics studies of phosphorylation and nitration and implication of these PTMs in tumorigenesis

    University dissertation from Stockholm : Karolinska Institutet, Dept of Oncology-Pathology

    Author : Min Jia; Karolinska Institutet.; Karolinska Institutet.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Breast cancer is the most common cancer in women. Even though improvements in diagnosis and treatment of breast cancer have been made, it is still the most common cause of cancer death in women. There is a great need to find biomarkers for early detection of the disease and novel drug targets to fight the cancer. READ MORE

  4. 4. Visualizing Interacting Biomolecules In Situ

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Irene Weibrecht; Uppsala universitet.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proximity ligation; in situ PLA; padlock probe; rolling circle amplification; flow cytometry; in situ; single cell; single molecule; protein interaction; protein-DNA interaction; posttranslational modification; MEDICINE Morphology; cell biology; pathology Pathology Molecular medicine; MEDICIN Morfologi; cellbiologi; patologi Patologi Molekylär medicin; Molekylär medicin; Molecular Medicine;

    Abstract : Intra- and intercellular information is communicated by posttranslational modifications (PTMs) and protein-protein interactions, transducing information over cell membranes and to the nucleus. A cells capability to respond to stimuli by several highly complex and dynamic signaling networks provides the basis for rapid responses and is fundamental for the cellular collaborations required in a multicellular organism. READ MORE

  5. 5. Development and Application of Proximity Assays for Proteome Analysis in Medicine

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Felipe Marques Souza de Oliveira; Uppsala universitet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Solid-phase proximity ligation assay; post-translational modifications; glycosylation; phosphorylation; Enzyme-linked immunosorbent assay; immunoassay and rolling circle amplification; Proximity Extension Assay; inflammation protein biomarkers; autoantibodies; autoimmune disease;

    Abstract : Along with proteins, a myriad of different molecular biomarkers, such as post-translational modifications and autoantibodies, could be used in an attempt to improve disease detection and progression. In this thesis, I build on several iterations of the proximity ligation assay to develop and apply new adaptable methods to facilitate detection of proteins, autoantibodies and post-translational modifications. READ MORE