Search for dissertations about: "PTMs"

Showing result 16 - 20 of 29 swedish dissertations containing the word PTMs.

  2. 16. Arthritogenic and immunogenic properties of modified autoantigens

    Author : Karin Lundberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Post-translational modifications; pH; chlorination; citrullination; CII; CIA; RA;

    Abstract : Rheumatoid arthritis is a chronic inflammatory joint disorder with autoimmune features in which both genetic and environmental factors are potential contributors to the arthritogenic process. In this thesis work we aimed to increase the understanding of early pathogenic events underlying the development of this complex disease by investigating the arthritogenic and immunogenic properties of modified autoantigens in experimental settings as well as in RA patients. READ MORE

  4. 17. p53-dependent and -independent mechanisms of p53-targeting small molecules

    Author : Jiawei Zhu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Tumor suppressor p53 (Tp53) is mutated in around half of human cancers, while in wild type p53 cells its activity is continuously inhibited by MDM2 through proteasome degradation resulting in the loss of its function. Currently, cancer treatments with small molecules based on reactivation of wild type p53 and restoration of mutant p53 have moved to clinical trials and exhibited promising anti-cancer effects. READ MORE

  5. 18. TGF-beta signaling in carcinogenic transformation of breast epithelial cells, using proteomics

    Author : Nimesh Bhaskaran; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Transforming growth factor-beta (TGFbeta) is a key regulator of cell proliferation, death, migration and differentiation. One of the features of TGFbeta signaling is to inhibit tumor growth at the early stage of cancer but promotes tumorigenesis at the advanced stage. READ MORE

  6. 19. Compact-disc microfluidic methods for characterization of therapeutic antibodies : Analysis of post-translational modifications

    Author : Thi Thuy Tran; Gunnar Thorsén; McLean John; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Microfluidic CD; therapeutic antibodies; post-translational modifications; glycosylation profiling; multivariate statistical analysis; MALDI-MS; Analytical Chemistry; analytisk kemi;

    Abstract : Characterization of post-translational modifications (PTMs) of therapeutic proteins is very important during the bioprocess development to maintain desired product quality and during the submission process to regulatory authorities for product approval. Monitoring glycosylation in pharmacokinetic studies can be useful to evaluate the dependence of clearance rates on different glycoforms. READ MORE

  7. 20. An exPADItion for citrullination in the developing hair follicle

    Author : Kim Vikhe Patil; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : During epidermal development, to assure proper tissue structure, highly complex transcriptional networks interact within the stem cell compartments of the epidermis and hair follicles (HFs) to balance the choice between self-renewal or differentiation. The full characterisation of the protein profiles resulting from those transcriptional networks, within the compartments of the HF, remains, however, incomplete. READ MORE