Search for dissertations about: "PTPN22"

Showing result 11 - 15 of 20 swedish dissertations containing the word PTPN22.

  2. 11. Genomic profiling and gene-gene interaction in rheumatoid arthritis

    Author : Klementy Shchetynsky; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Complex disease is characterized by the interplay of multiple genetic and environmental factors. Rheumatoid arthritis (RA) is a complex autoimmune disease with a pronounced genetic component, mainly due to HLA-DRB1 gene, but also a multitude of loci outside the HLA region. READ MORE

  4. 12. Immunogenetics of Childhood Type 1 Diabetes in Immigrant Patients in Sweden. Migration Studies on Type 1 Diabetes

    Author : Ahmed Delli; Celiaki och diabetes; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes; Type 1 Diabetes; Childhood; Human Leukocyte Antigen HLA ; Islet autoantibodies; Zinc Transporter 8 ZnT8 ; Islet antigen IA2- ; Glutamic Acid Decarboxylase 65 GAD65; Insulin; Migration.;

    Abstract : This thesis examined whether the offspring of immigrants (non-Swedes) to Sweden are at increased risk of Type 1 Diabetes (T1D) when they are born or live in Sweden. It also evaluated if their T1D and T2D-related genes differed from Swedish patients and whether this genetic heritage determined the types and existence of islet autoantibodies at time of diagnosis and affected the classification of diabetes. READ MORE

  5. 13. The Genetics of Systemic Lupus Erythematosus : The Specificity of IRF5 to SLE

    Author : MV Prasad Linga Reddy; Marta Alarcön Riquelme; Dan Holmberg; Uppsala universitet; []
    Keywords : Molecular genetics; Systemic lupus erythematosus; Interferon regulatory factor 5; Transmission-Disequilibrium Test; Family-based association test; Linkage Disequilibrium; Hardy-Weinberg equilibrium; Genetik;

    Abstract : The breakdown of self-tolerance is the main driving force behind susceptibility to SLE. When this occurs, T and B cells are activated in an uncontrolled manner and produce autoantibodies against self fragmented DNA, RNA and sometimes other parts of the cell such as cardiolipin, phosphatidylserine, etc. READ MORE

  6. 14. Genetic and genomic analysis of arthritis regulating regions in human and mouse

    Author : Lina Olsson; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatology locomotion; Skelett; muskelsystem; reumatologi; Immunologi; serologi; transplantation; Skeleton; muscle system; serology; Immunology; Medicin människa och djur ; Medicine human and vertebrates ; QTL; NADPH oxidase complex; Rheumatoid Arthritis; Genetic Analysis;

    Abstract : Identifying genes involved in the disease pathways of complex diseases such as Rheumatoid arthritis (RA) has been shown to be very difficult. Despite decades of research still only a handful of genes have been convincingly identified as risk genes. READ MORE

  7. 15. Genetic analysis of candidate susceptibility genes for type 1 diabetes

    Author : Samina Asad; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Type 1 diabetes (T1D) is a complex disease where the pancreatic β-cells are destroyed in an autoimmune attack. For the patients, this leads to lifelong daily insulin treatment and increased risk for various kinds of complications. It is thought that both environmental as well as genetic factors act in concert to cause T1D. READ MORE