Search for dissertations about: "PTPN22"
Showing result 16 - 20 of 20 swedish dissertations containing the word PTPN22.
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16. Investigations of Porphyromonas gingivalis as a possible trigger of autoimmunity in the development of rheumatoid arthritis
Abstract : Rheumatoid Arthritis (RA) is a severe autoimmune disease affecting 0.5-1% worldwide. Patients suffer from pain, disability, chronic joint inflammation, comorbidities and increased mortality. Although, the aetiology of RA is largely unknown, both genes and environment have been shown to contribute. READ MORE
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17. Genetic studies of the HLA locus in rheumatic diseases
Abstract : Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) share a complex etiology consisting of both genetic and environmental components. Stimulation of lymphocytes and various other immune cells, release of cytokines, activation of complement and production of autoantibodies due to loss of tolerance to self-antigens, contributes to the pathogenesis of both RA and SLE. READ MORE
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18. Psoriatic arthritis: a complex disease : analyses on genetic and serological biomarkers and of comorbidity
Abstract : Psoriatic Arthritis (PsA) is a heterogonous inflammatory arthritis associated with psoriasis. The disease leads to inflammation of peripheral joints, axial skeleton and/or enthesites, and can result in severe destruction of affected joints. READ MORE
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19. Genetic studies of diabetes in northern Sweden
Abstract : Diabetes mellitus represents a group of metabolic disorders caused by both environmental and genetic factors. The two most common forms of diabetes are type 2 diabetes (T2D) and type 1 diabetes (T1D). T2D is associated with obesity and the disease is caused by insulin resistance and pancreatic b-cell dysfunction. READ MORE
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20. Genetic factors predisposing to myasthenia gravis and related autoimmune disorders
Abstract : Myasthenia gravis (MG) is an autoimmune disorder in which patients experience weakness of the skeletal or ocular-bulbar muscles. In most patients, anti-AChR antibodies affect the signal across the neuromuscular junction necessary for muscular contraction. READ MORE