Search for dissertations about: "PU.l"

Found 1 swedish dissertation containing the word PU.l.

2. 1. Transcription factors regulating the Btk promoter

   Author : Susanne Müller; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Btk; X-linked agammaglobulinemia; transcription factors; repression; synergism; Sp 1; Sp3; PU.l; Spi-B; genetherapy.;

   Abstract : Bruton's agammaglobulinemia tyrosine kinase (Btk) is a cytoplasmic tyrosine kinase-related to the Src family of kinases. Mutations in various parts of the gene have been shown to lead to X-linked agammaglobulinemia, an immunodeficiency disease which is characterized by a defect in B-cell development. READ MORE