Search for dissertations about: "Padlock probes"

Showing result 21 - 25 of 27 swedish dissertations containing the words Padlock probes.

2. 21. Single Molecule Detection : Microfluidic Automation and Digital Quantification

   Author : Malte Kühnemund; Mats Nilsson; Ulf Landegren; Sten Linnarsson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; single molecule; digital; rolling circle amplification; magnetic particle; padlock probe; microfluidics; resistive pulse sensing; lab on chip; mobile phone microscopy; enrichment; sequencing;

   Abstract : Much of recent progress in medical research and diagnostics has been enabled through the advances in molecular analysis technologies, which now permit the detection and analysis of single molecules with high sensitivity and specificity. Assay sensitivity is fundamentally limited by the efficiency of the detection method used for read-out. READ MORE

4. 22. Molecular Tools for Biomarker Detection

   Author : Lei Chen; Ulf Landegren; Niko Hildebrandt; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Rolling circle amplification; padlock probe;

   Abstract : The advance of biological research promotes the emerging of new methods and solutions to answer the biological questions. This thesis describes several new molecular tools and their applications for the detection of genomic and proteomic information with extremely high sensitivity and specificity or simplify such detection procedures without compromising the performance. READ MORE

5. 23. Single-molecule Detection in situ

   Author : Chatarina Larsson; Mats Nilsson; Ulf Landegren; Sanjay Tyagi; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular medicine; Molekylär medicin; Molecular Medicine; molekylär medicin genetik och patologi ;

   Abstract : The human body contains a variety of different cell types that share a common genome, but differ in how they use the information encoded therein. Variation in molecular content exists even at the level of individual cells, and to provide deeper insight into complex cellular processes methods that permit analysis of each cell on its own are needed. READ MORE

6. 24. Molecular detection and characterization of drug-resistant Mycobacterium tuberculosis

   Author : Anna Engström; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Tuberculosis (TB) is an ancient disease, but not a disease of the past. Despite the declaration of TB as a global emergency by the World Health Organization in 1993 the worldwide problem of TB has worsened. READ MORE

7. 25. Influenza Neuraminidase : Conserved features of a rapidly mutating virus

   Author : Henrik Östbye; Pia Ädelroth; Anice Lowen; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; influenza; virology; neuraminidase; biokemi; Biochemistry;

   Abstract : Influenza A viruses (IAVs) of the H1N1 and H3N2 serotypes are the major cause of seasonal influenza epidemics. IAVs are labeled based on the antigenic properties of the two surface glycoproteins and main antigens: hemagglutinin (HA/H) and neuraminidase (NA/N). READ MORE