Search for dissertations about: "Pancreatic elastase"
Showing result 1 - 5 of 6 swedish dissertations containing the words Pancreatic elastase.
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1. Enzyme Cold Adaptation through Evolution of Protein Flexibility
Abstract : What lives, evolves. Macromolecular catalysis is a process, central to both evolutionary and metabolic aspect of life, as it provides a systematic bias favouring certain chemical processes. READ MORE
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2. Clinical consequences of pancreatic exocrine insufficiency
Abstract : Background: Chronic pancreatitis (CP) is characterized by a chronic inflammation with fibrosis and irreversible morphological changes that can result in permanent structural changes with a loss of exocrine and endocrine pancreas function. Exocrine dysfunction leads to reduced production of pancreatic digestive enzymes which is the reason of maldigestion and malabsorption of ingested nutrients like fats, microelements, vitamins and proteins which can lead to osteopathy. READ MORE
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3. Secretory Leukocyte Protease Inhibitor (SLPI) in the gastrointestinal tract in man
Abstract : Secretory leukocyte protease inhibitor is a 11.7 kDa acid stable serine protease inhibitor. SLPI has been shown to be the dominant protease inhibitor in bronchial secretions and has been used in treatment of pulmonary emphysema. READ MORE
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4. Fishing for small molecules to treat diabetes, from a beta cell perspective
Abstract : Maintenance of glucose homeostasis necessitates a precise control of insulin secretion. Pancreatic β cells sense fluctuation of blood glucose and secret insulin in response. However, functional β cell mass is decreased in diabetes. Here, to recover functional β cell mass, we use zebrafish as a model to perform in vivo drug discovery. READ MORE
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5. Characterization of conjugated protease inhibitors
Abstract : The overall theme of this thesis is a step by step approach for the design and characterization of conjugated protease inhibitors. This involves both a new assay method for protease activity and protease inhibition (paper I), a study of the stoichiometry for protease inhibitor interaction (paper II), design of inhibitory peptides (paper IV) and the construction of inhibitor conjugates (paper III & IV). READ MORE