Search for dissertations about: "Paolo Carloni"
Found 2 swedish dissertations containing the words Paolo Carloni.
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1. Quantum Chemical Studies of Chemotherapeutic Drug Cisplatin : Activation and Binding to DNA
Abstract : The serendipitous discovery of the potent cytotoxic properties of cisplatin brought about a revolution in the treatment of certain types of cancer, but almost fifty years later, there still remain unknown areas in the chemistry of cisplatin. There are questions regarding which form of the drug reaches its DNA target, or why certain DNA sequences are more preferred than others for reaction with cisplatin. READ MORE
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2. Voltage sensor activation and modulation in ion channels
Abstract : Voltage-gated ion channels play fundamental roles in neural excitability, they are for instance responsible for every single heart beat in our bodies, and dysfunctional channels cause disease that can be even lethal. Understanding how the voltage sensor of these channels function is critical for drug design of compounds targeting neuronal excitability. READ MORE