Search for dissertations about: "Parallel kinetic resolution"
Found 5 swedish dissertations containing the words Parallel kinetic resolution.
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1. Chemoenzymatic Resolution in Dynamic Systems : Screening, Classification and Asymmetric Synthesis
Abstract : This thesis is divided into four parts, all centered around Constitutional Dynamic Chemistry (CDC) and Dynamic Kinetic Resolution (DKR) using biocatalysts for selective transformations, and their applications in screening of bioactive compounds, organic synthesis, and enzyme classification. In part one, an introduction to CDC and DKR is presented, illustrating the basic concepts, practical considerations and potential applications of such dynamic systems, thus providing the background information for the studies in the following chapters. READ MORE
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2. Methods for Asymmetric Olefination Reactions; Development and Application to Natural Product Synthesis
Abstract : This thesis deals with the development and application of methods for asymmetric olefinations, in particular Horner-Wadsworth-Emmons (HWE) reactions, in the synthesis of certain natural products. Relying on asymmetric HWE reactions to access key building blocks, two natu-ral products, pyranicin and pyragonicin, were synthesized from common late intermediates. READ MORE
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3. Resolution of Dynamic Systems: Applications in Asymmetric Synthesis and Materials Science
Abstract : This thesis is built on the concepts of constitutional dynamic chemistry and dynamic kinetic resolution, where reversible covalent reactions are used to generate dynamics and kinetically controlled reactions are employed for resolution. The thesis is divided into two parts:The first section focuses on the study of dynamic systemic resolution, a concept derived from constitutional dynamic chemistry. READ MORE
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4. Reducing Attrition via Improved Strategies for Pre-clinical Drug Discovery : SPR-biosensor Aided Interaction Studies
Abstract : The efficacy of a drug is tightly intertwined with its interaction mechanism with the drug target. The mechanism is dependent on the physicochemical and structural characteristics of both target and drug molecule.Drug discovery is plagued by a high attrition rate, whereas in the clinic, a major issue is drug resistance. READ MORE
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5. Biocatalytic transamination with recombinant Saccharomyces cerevisiae: Challenges and opportunities
Abstract : Chiral building blocks are important molecules for synthesis of fine chemicals and pharmaceuticals. Biocatalysis has gained in relevance over traditional organic methods for synthesis of chiral compounds, as reactions can be performed at high enantio-selectivity and purity with environmentally friendly, simple, and cheap methods. READ MORE