Search for dissertations about: "Paraskevi Heldin"

Showing result 1 - 5 of 6 swedish dissertations containing the words Paraskevi Heldin.

  2. 1. Regulation of Hyaluronan Synthesis and Signaling via CD44 in Cancer

    Author : Merima Mehić; Paraskevi Heldin; Carl-Henrik Heldin; Liliana Schaefer; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hyaluronan; CD44; TGFβ; PDGF-BB; cancer; signaling; hyaluronan synthase; epithelial-mesenchymal transition; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Medical Science; Medicinsk vetenskap;

    Abstract : Hyaluronan is a ubiquitous glycosaminoglycan which is an important constituent of the extracellular matrix (ECM). In addition to organizing the extracellular matrix and regulating tissue homeostasis, hyaluronan, by binding to its main cell surface receptor CD44, is involved in intracellular signaling pathways regulating major cellular processes during development, wound healing, inflammation and cancer. READ MORE

  4. 2. Studies on the phosphorylation of fibrinogen

    Author : Paraskevi Heldin; Uppsala universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : .... READ MORE

  5. 3. Importance of Hyaluronan Metabolism and Signalling in Tumour Progression

    Author : Berit Bernert; Paraskevi Heldin; Peter Prehm; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hyaluronan; CD44; cancer; growth factors;

    Abstract : Hyaluronan, an unbranched glycosaminoglycan of the extracellular matrix, has an amazingly simple structure. Initially thought to fulfil only hydrating and space-filling functions in tissues, evidence generated during the past decades shows that hyaluronan is involved in intriguingly complex signalling events in health and disease. READ MORE

  6. 4. Effect of Hyaluronan-activation of CD44 on Cell Signaling and Tumorigenesis

    Author : Lingli Li; Paraskevi Heldin; Raija H. Tammi; Uppsala universitet; []
    Keywords : Biomedicine; Hyaluronan; CD44; growth factors; chemokines; tumorigenesis; wound healing; cell signaling; Biomedicin;

    Abstract : Hyaluronan (HA), a structural component in the extracellular matrix (ECM), has been recognized as a signaling molecule. It is important during various biological activities such as embryogenesis, angiogenesis, wound healing and tumor progression. READ MORE

  7. 5. The role of hyaluronan and its CD44 receptor in inflammation and cancer

    Author : Chun-Yu Lin; Jyrki Tenhunen; Miklós Lipcsey; Paraskevi Heldin; Markku Tammi; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD44; Dengue; Hyaluronan; HAS2; iASPP; TGFbeta; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Hyaluronan, an important extra-cellular matrix molecule, was thought to be interstitial connecting glue decades ago. However, recent evidence has revealed that hyaluronan and its binding proteins also play crucial roles in various pathophysiological conditions in humans, including inflammation and infection. READ MORE