Search for dissertations about: "Parkinsonism"

Showing result 1 - 5 of 38 swedish dissertations containing the word Parkinsonism.

  1. 1. Idiopathic parkinsonism epidemiology and clinical characteristics of a population-based incidence cohort

    University dissertation from Umeå : Umeå universitet

    Author : Jan Linder; Umeå universitet.; Umeå universitet.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinsonism; Parkinson s disease; Multiple system atrophy; Progressive supranuclear palsy; Incidence; Magnetic resonance tomography; Electromyography; Oculomotor;

    Abstract : Background: Idiopathic parkinsonism is a neurodegenerative syndrome of unknown cause and includes Parkinson’s disease (PD) and atypical parkinsonian disorders. The atypical parkinsonian disorders are: Multiple system atrophy (MSA), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). READ MORE

  2. 2. Nuclear medicine methods in idiopathic Parkinsonism pre- and postsynaptic dopamine SPECT

    University dissertation from Umeå : Umeå Universitet

    Author : Susanna Jakobson Mo; Umeå universitet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Nuclear medicine; SPECT; 123I-FP-Cit; 123I-IBZM; dopamine; parkinsonism; Parkinson’s disease; multiple system atrophy; progressive supranuclear palsy; Radiology; radiologi;

    Abstract : Background: Single photon emission computed tomography (SPECT) with dopamine transporter (DAT) and dopamine D2 receptor (D2R) ligands can visualise the integrity of the nigrostriatal dopamine system. Parkinson’s disease (PD) and the atypical parkinsonian diseases (APD), progressive supranuclear palsy (PSP) and multiple system atrophy (MSA), have similar symptoms and dopamine depletion, but differ in pharmacological response and prognosis. READ MORE

  3. 3. Melanin binding of MPTP and related substances, and manganese : possible connection with parkinsonism

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Annika Lydén Sokolowski; Uppsala universitet.; [1990]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : .... READ MORE

  4. 4. Heredity in Parkinson's disease. From rare mutations to common genetic risk factors

    University dissertation from Lund University

    Author : Andreas Puschmann; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease; parkinsonism; genetics; alpha-synuclein; SNCA duplicaion; SNCA triplication; LRRK2; PARKIN; PARK2; VPS35; EIF4G1; rare variants; digenic inheritance; heritability;

    Abstract : This study investigated genetic causes of Parkinson's disease (PD) and parkinsonism in southern Sweden. The extensive Lister Family with parkinsonism caused by duplications and triplications of the gene for alpha-synuclein (SNCA) was studied. Clinical, genetic and genealogical data were compiled and evaluated. READ MORE

  5. 5. Selective Retention of β-Carbolines and 7,12-Dimethylbenz[a]anthracene in the Brain Role of Neuromelanin and Cytochrome P450 for Toxicity

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Anna Östergren; Uppsala universitet.; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; β-carboline; neuromelanin; norharman; harman; parkinsonism; Parkinson s disease; motoric impairment; behaviour; glia cells; substantia nigra; dopamine melanin; PC12 cells; ER stress; grp78; hsp90; cytochrome P450; CYP1A1; CYP1B1; blood-brain interfaces; 7; 12-dimethylbenz[a]anthracene; polycyclic aromatic hydrocarbon; endothelial cell; smooth muscle cell; bioactivation; Toxikologi; PHARMACY Toxicology; FARMACI Toxikologi; Toxicology; toxikologi;

    Abstract : The ß-carbolines norharman and harman structurally resemble the synthetic compound 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) that is known for its ability to damage neuromelanin-containing dopaminergic neurons of the substantia nigra and thereby induce parkinsonism. MPTP is, however, not normally present in the environment whereas the ß-carbolines are present in cooked food and tobacco smoke. READ MORE