Search for dissertations about: "Partial-filling technique"

Showing result 1 - 5 of 7 swedish dissertations containing the words Partial-filling technique.

  2. 1. Enantiomeric separation by capillary electrophoresis : With special emphasis on the partial filling technique

    Author : Ahmad Amini; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; analytisk farmaceutisk kemi; Analytical Pharmaceutical Chemistry;

    Abstract : Capillary electrophoresis as a powerful separation technique was employed for resolution of racemic drugs. Taurodeoxycholate (TDC), different cyclodextrins and α1- acid glycoprotein (AGP) were dissolved in the background electrolyte at low pH (3.0 to 4.0 ) as chiral selectors. READ MORE

  4. 2. Studies of Micellar Electrokinetic Chromatography as an Analytical Technique in Pharmaceutical Analysis - an Industrial Perspective

    Author : Karin Stubberud; Brian J. Clark; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Micellar Electrokinetic Chromatography; Pharmaceutical Analysis; Chemometrics; Validation; Mass Spectrometry; Partial-filling technique; Pilocarpine; Ibuprofen; Codeine.; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; analytisk farmaceutisk kemi; Analytical Pharmaceutical Chemistry;

    Abstract : Studies have been performed to evaluate the use of micellar electrokinetic chromatography (MEKC), one mode of capillary electrophoresis (CE), as an analytical technique in industrial pharmaceutical analysis. The potential for using chemometrics for the optimisation of MEKC methods has also been studied as well as the possibilities of coupling MEKC with mass spectrometry (MS). READ MORE

  5. 3. Separation of Pharmaceuticals by Capillary Electrophoresis using Partial Filling and Multiple-injections

    Author : Henrik Lodén; Curt Pettersson; Torbjörn Arvidsson; Ahmad Amini; Morgan Stefansson; Uppsala universitet; []
    Keywords : Capillary Coating; Chiral Separation; Enantiomers; Mass-spectrometric Detection; Method Validation; Multiple-injection Capillary Zone Electrophoresis; Non-aqueous Capillary Electrophoresis; Organic Solvents; Pharmaceutical Analysis; Quantitative Analysis;

    Abstract : Different multiple-injection methodologies and the partial filling technique (PFT) have been utilized for separation of pharmaceuticals by capillary elec-trophoresis. In multiple-injection capillary zone electrophoresis (MICZE), the samples and all standards, used for construction of the calibration curve, are analyzed within a single run. READ MORE

  6. 4. Development of Methods in CE, CE-MS and MS/MS : Applications in Pharmaceutical, Biomedical and Forensic sciences

    Author : Emmy Jäverfalk-Hoyes; Jonas Bergquist; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; analytisk farmaceutisk kemi; Analytical Pharmaceutical Chemistry;

    Abstract : Capillary electrophoresis-mass spectrometry has been used successfully for the analysis of a wide range of analytes such as chiral local anaesthetics, sulphonated reactive dyes and endogenous neurotransmitters and neuropeptides.The partial filling technique was used in CE-MS for chiral separation of bupivacaine and ropivacaine using the non-volatile selector β-cyclodextrin. READ MORE

  7. 5. Electrochemical Methods for Drug Characterisation and Transdermal Delivery : Capillary Zone Electrophoresis, Conductometry, and Iontophoresis

    Author : Nadia Merclin; Per Hansson; Sven Engström; Arto Urtti; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Capillary zone electrophoresis; precision conductometry; iontophoresis; passive diffusion; lidocaine; ALA; ALA-ester derivatives; sponge phase; carbopol gel; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

    Abstract : This thesis concerns the development and utilisation of techniques for characterisation and transdermal delivery of various systems for pharmaceutical applications.The degree of dissociation of drug molecules and the mobilities of the different species formed are essential factors affecting the rate of drug delivery by iontophoresis. READ MORE