Search for dissertations about: "Parvaneh Afsharian"

Found 1 swedish dissertation containing the words Parvaneh Afsharian.

2. 1. Optimization of cyclophosphamide therapy based on pharmacogenetics

   Author : Parvaneh Afsharian; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Cyclophosphamide; Pharmacogenetics; Pharmacokinetics; Cytochrome P450; CYP2136; Ciprofloxacin;

   Abstract : Cyclophosphamide (CPA) is one of the most broadly used anticancer agents. CPA is also a potent immunosuppressive agent that is used for the treatment of autoimmune diseases. CPA is a prodrug that is activated in liver by a 4-hydroxylation reaction catalyzed by cytochrome P450 (CYP) enzymes. READ MORE