Search for dissertations about: "Pathology topics"

Found 2 swedish dissertations containing the words Pathology topics.

  2. 1. The pathophysiology of respiratory chain dysfunction

    Author : José Pablo Silva; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Mitochondrial disease; mitochondrial DNA mtDNA ; mitochondrial transcription factor A Tfam ; Cre-loxP; conditional knockout; reactive oxygen species ROS ; superoxide; uncoupling protein UCP ; mitochondrial bioenergeties; energy expenditure;

    Abstract : Mutations of mitochondrial DNA cause a variety of clinical syndromes. It is unclear whether impaired oxidative phosphorylation on its own is the main cause of pathology or whether other factors such as secondary metabolic alterations, enhanced formation of reactive oxygen species (ROS) and induction of apoptosis also may contribute to the clinical phenotype. READ MORE

  4. 2. Application of the benchmark dose-response modelling approach for risk characterization of chemicals

    Author : Antero Vieira da Silva; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Toxicology is the discipline that investigates the possible adverse effects of chemical exposure on human, animal and environmental health. Chemical risk assessment is the process that aims to identify potentially hazardous substances and describes the probability of adverse outcomes associated with their exposure. READ MORE