Search for dissertations about: "Pathology"

Showing result 21 - 25 of 920 swedish dissertations containing the word Pathology.

  2. 21. TINT Tumor Indicating Normal Tissue : new field of diagnostic biomarkers for prostate cancer

    Author : Hanibal Hani Adamo; Anders Bergh; Göran Landberg; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prostate cancer; biomarkers; TINT; patologi; Pathology;

    Abstract : Background: Prostate cancer is the most common cancer in Sweden. Due its highly variable behavior, multifocal nature, and insufficient diagnostic methods, prostate cancer is difficult to diagnose and prognosticate. READ MORE

  4. 22. Biomarker Discovery in Cutaneous Malignant Melanoma : A Study Based on Tissue Microarrays and Immunohistochemistry

    Author : Margrét Agnarsdóttir; Fredrik Ponten; Peter Naredi; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antibody-based proteomics; automated analysis; biomarker; immunohistochemistry; malignant melanoma; survival; tissue microarray; Tumour biology; Tumörbiologi; Pathology; Patologi; Molecular medicine; Molekylär medicin; Medical Science; Medicinsk vetenskap; Pathology; Patologi;

    Abstract : The incidence of cutaneous malignant melanoma has increased dramatically in Caucasians the last few decades, an increase that is partly explained by altered sun exposure habits. For the individual patient, with a localized disease, the tumor thickness of the excised lesion is the most important prognostic factor. READ MORE

  5. 23. Molecular Studies of Mast Cell Migration and Apoptosis : Two Ways of Regulating Mast Cell Numbers at Sites of Inflammation

    Author : Jessica Alfredsson; Gunnar Nilsson; Hans-Uwe Simon; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; mast cell; SCF; IL-3; FcεRI; migration; apoptosis; Bim; Bcl-2; Bcl-XL; Akt; FOXO; MAPK; Patologi; Pathology; Patologi;

    Abstract : Upon activation mast cells release numerous proinflammatory mediators. With this feature, mast cells play an important role in host defense against pathogens, and are involved in tissue remodeling and wound healing. However, in cases of excessive inflammation the effects of mast cells are detrimental. READ MORE

  6. 24. Studies on Human Endogenous Retroviruses (HERVs) with Special Focus on ERV3

    Author : Ann-Catrin Andersson; Bengt Widegren; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; human endogenous retroviruses; HERV; ERV3; expression; in situ hybridisation; real-time PCR; U-937; retinoic acid.; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Abstract : Human endogenous retroviruses (HERVs) represent approximately 7% of the human genome. This investigation was focused on one particular HERV, ERV3, with the main purpose of characterising its gene expression patterns and genomic distribution of ERV3-like sequences. READ MORE

  7. 25. Significance of Wilms’ tumor gene 1 as a biomarker in acute leukemia and solid tumors

    Author : Charlotta Andersson; Eva Lundin; Aihong Li; Andreas Jonsson; Xingru Li; David M. Loeb; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Wilms’ tumor gene 1; biomarker; leukemia; renal cell carcinoma; ovarian carcinoma; Clinical Chemistry; klinisk kemi; patologi; Pathology;

    Abstract : Wilms’ tumor gene 1 (WT1) is a zinc finger transcriptional regulator with crucial functions in embryonic development. Originally WT1 was described as a tumor suppressor gene, but later studies have shown oncogenic properties of WT1 in a variety of tumors. Because of its dual functions in tumorigenesis, WT1 has been described as a chameleon gene. READ MORE