Search for dissertations about: "Patrick Midoux"

Found 1 swedish dissertation containing the words Patrick Midoux.

  2. 1. Characterization of nucleic acid delivery with fatty acid modified cell-penetrating peptide nanoparticle formulations

    Author : Tõnis Lehto; Ülo Langel; Patrick Midoux; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Transfection; gene delivery; oligonucleotide; complexes; non-viral; in vivo; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Recent advances with techniques used for manipulating gene expression have brought us to an era where various gene therapeutic approaches are becoming common therapeutic tools for many previously incurable diseases. The main factor impeding the wider translation of gene therapy is that the active pharmaceutical ingredients used for interfering with gene expression are based on nucleic acids and synthetic oligonucleotides and such molecules do not readily reach their intracellular targets due to their physicochemical properties and therefore they require delivery vectors to cross the cell membrane. READ MORE